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ZNF510 zinc finger protein 510 [ Homo sapiens (human) ]

Gene ID: 22869, updated on 1-Jun-2020

Summary

Official Symbol
ZNF510provided by HGNC
Official Full Name
zinc finger protein 510provided by HGNC
Primary source
HGNC:HGNC:29161
See related
Ensembl:ENSG00000081386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a krueppel C2H2-type zinc-finger protein family member. The encoded protein is expressed in several cancer cell types and may be a biomarker for early diagnosis of these cancers. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in brain (RPKM 3.5), thyroid (RPKM 3.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF510 in Genome Data Viewer
Location:
9q22.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (96754549..96778549, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99518147..99540401, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene peroxiredoxin like 2C Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene zinc finger protein 782 Neighboring gene cyclin Y like 1 pseudogene Neighboring gene prothymosin alpha pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0972, MGC33740

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314059.2NP_001300988.1  zinc finger protein 510 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL589843, BC036676, BI467226
    Consensus CDS
    CCDS35074.1
    UniProtKB/Swiss-Prot
    Q9Y2H8
    UniProtKB/TrEMBL
    Q6NUI8
    Related
    ENSP00000364379.1, ENST00000375231.5
    Conserved Domains (6) summary
    smart00349
    Location:46105
    KRAB; krueppel associated box
    COG5048
    Location:240663
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:406426
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:404426
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4685
    KRAB; KRAB box
    pfam13465
    Location:587611
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001314060.2NP_001300989.1  zinc finger protein 510 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL589843, BI467226, DA496439
    Conserved Domains (6) summary
    smart00349
    Location:143
    KRAB; krueppel associated box
    COG5048
    Location:178601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:342364
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:123
    KRAB; KRAB box
    pfam13465
    Location:525549
    zf-H2C2_2; Zinc-finger double domain
  3. NM_014930.2NP_055745.1  zinc finger protein 510 isoform 1

    See identical proteins and their annotated locations for NP_055745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AB023189, AL589843, BI467226
    Consensus CDS
    CCDS35074.1
    UniProtKB/Swiss-Prot
    Q9Y2H8
    Related
    ENSP00000223428.4, ENST00000223428.8
    Conserved Domains (6) summary
    smart00349
    Location:46105
    KRAB; krueppel associated box
    COG5048
    Location:240663
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:406426
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:404426
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4685
    KRAB; KRAB box
    pfam13465
    Location:587611
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    96754549..96778549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518393.2XP_011516695.1  zinc finger protein 510 isoform X3

    See identical proteins and their annotated locations for XP_011516695.1

    Conserved Domains (6) summary
    smart00349
    Location:143
    KRAB; krueppel associated box
    COG5048
    Location:178601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:344364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:342364
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:123
    KRAB; KRAB box
    pfam13465
    Location:525549
    zf-H2C2_2; Zinc-finger double domain
  2. XM_005251808.2XP_005251865.1  zinc finger protein 510 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:46105
    KRAB; krueppel associated box
    COG5048
    Location:239662
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:403425
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4685
    KRAB; KRAB box
    pfam13465
    Location:586610
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017014483.1XP_016869972.1  zinc finger protein 510 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2H8
    Conserved Domains (6) summary
    smart00349
    Location:46105
    KRAB; krueppel associated box
    COG5048
    Location:240663
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:406426
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:404426
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4685
    KRAB; KRAB box
    pfam13465
    Location:587611
    zf-H2C2_2; Zinc-finger double domain
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