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DOLK dolichol kinase [ Homo sapiens (human) ]

Gene ID: 22845, updated on 7-Jun-2020

Summary

Official Symbol
DOLKprovided by HGNC
Official Full Name
dolichol kinaseprovided by HGNC
Primary source
HGNC:HGNC:23406
See related
Ensembl:ENSG00000175283 MIM:610746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DK; DK1; CDG1M; SEC59; TMEM15
Summary
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
Orthologs

Genomic context

See DOLK in Genome Data Viewer
Location:
9q34.11
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128945530..128947603, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131707809..131710012, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 8 VRAC subunit A Neighboring gene uncharacterized LOC101929291 Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene nucleoporin 188 Neighboring gene uncharacterized LOC101929314 Neighboring gene SH3 domain containing GRB2 like, endophilin B2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dolichol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dolichol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
dolichol kinase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
dolichyl diphosphate biosynthetic process TAS
Traceable Author Statement
more info
 
dolichyl monophosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dolichyl monophosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dolichol kinase
Names
SEC59 homolog
dolichol kinase 1
transmembrane protein 15
NP_055723.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017009.1 RefSeqGene

    Range
    5001..7204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_744

mRNA and Protein(s)

  1. NM_014908.4NP_055723.1  dolichol kinase

    See identical proteins and their annotated locations for NP_055723.1

    Status: REVIEWED

    Source sequence(s)
    BC035556, BF056649
    Consensus CDS
    CCDS6915.1
    UniProtKB/Swiss-Prot
    Q9UPQ8
    UniProtKB/TrEMBL
    A0A0S2Z597
    Related
    ENSP00000361667.3, ENST00000372586.4
    Conserved Domains (1) summary
    cl21502
    Location:337524
    CTP_transf_1; Cytidylyltransferase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128945530..128947603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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