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DLGAP4 DLG associated protein 4 [ Homo sapiens (human) ]

Gene ID: 22839, updated on 29-Jan-2024

Summary

Official Symbol
DLGAP4provided by HGNC
Official Full Name
DLG associated protein 4provided by HGNC
Primary source
HGNC:HGNC:24476
See related
Ensembl:ENSG00000080845 MIM:616191; AllianceGenome:HGNC:24476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP4; DLP4; DAP-4; SAPAP4; SAPAP-4
Summary
The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 12.5), endometrium (RPKM 11.0) and 25 other tissues See more
Orthologs
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Genomic context

See DLGAP4 in Genome Data Viewer
Location:
20q11.23
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (36306339..36528633)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (38027049..38252509)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34894261..35157036)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 1 Neighboring gene uncharacterized LOC105372602 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:34858840-34860039 Neighboring gene AAR2 splicing factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34959277-34959938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34959939-34960600 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:34960601-34961262 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34961263-34961922 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:34961923-34962584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34964801-34965786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34966822-34967482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34968805-34969464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34969762-34970692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34978479-34978979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34980118-34980829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:34996041-34996689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35060233-35060734 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:35069878-35070075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35082739-35083539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35089423-35090213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35090214-35091004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35093338-35094263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35092411-35093337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17807 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35100944-35101844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35125835-35126334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17808 Neighboring gene DLGAP4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35170723-35171376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35171377-35172030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35172031-35172684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35172685-35173338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:35175959-35176887 Neighboring gene NANOG hESC enhancer GRCh37_chr20:35191013-35191578 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr20:35199946-35200498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12875 Neighboring gene TGIF2-RAB5IF readthrough Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35213881-35214870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35217734-35218362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:35219932-35220810 Neighboring gene myosin light chain 9 Neighboring gene TGFB induced factor homeobox 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of discs, large (Drosophila) homolog-associated protein 4 (DLGAP4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20588, KIAA0964, MGC131862

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signaling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cholinergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
disks large-associated protein 4
Names
PSD-95/SAP90-binding protein 4
SAP90/PSD-95-associated protein 4
discs large homolog associated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042486.4NP_001035951.1  disks large-associated protein 4 isoform c

    See identical proteins and their annotated locations for NP_001035951.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 5' exons but contains alternate 5' exon structure, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AI984397, AK001681, AL050318, BC153874
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Related
    ENSP00000477723.1, ENST00000475894.5
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. NM_001365621.2NP_001352550.1  disks large-associated protein 4 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374, AL445705, AL512784
    Consensus CDS
    CCDS93034.1
    UniProtKB/Swiss-Prot
    E1P5T5, Q5QPG4, Q5T2Y4, Q5T2Y5, Q9H137, Q9H138, Q9H1L7, Q9Y2H0
    Related
    ENSP00000341633.5, ENST00000339266.10
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  3. NM_001388257.1NP_001375186.1  disks large-associated protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  4. NM_001388260.1NP_001375189.1  disks large-associated protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  5. NM_001388262.1NP_001375191.1  disks large-associated protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  6. NM_001388265.1NP_001375194.1  disks large-associated protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  7. NM_001388268.1NP_001375197.1  disks large-associated protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  8. NM_001388271.1NP_001375200.1  disks large-associated protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  9. NM_001388274.1NP_001375203.1  disks large-associated protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  10. NM_001388275.1NP_001375204.1  disks large-associated protein 4 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    UniProtKB/TrEMBL
    A0A0B4J2C2
    Conserved Domains (1) summary
    pfam03359
    Location:1285
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  11. NM_001388277.1NP_001375206.1  disks large-associated protein 4 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    Conserved Domains (1) summary
    pfam03359
    Location:17298
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  12. NM_001388278.1NP_001375207.1  disks large-associated protein 4 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL050318, AL390374
    Conserved Domains (1) summary
    pfam03359
    Location:108450
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  13. NM_014902.6NP_055717.2  disks large-associated protein 4 isoform a

    See identical proteins and their annotated locations for NP_055717.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB023181, AI984397, AL050318, AL120584, AL390374
    Consensus CDS
    CCDS13274.1
    UniProtKB/Swiss-Prot
    Q9Y2H0
    Related
    ENSP00000363023.3, ENST00000373913.7
    Conserved Domains (1) summary
    pfam03359
    Location:650989
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  14. NM_183006.4NP_892118.1  disks large-associated protein 4 isoform b

    See identical proteins and their annotated locations for NP_892118.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons but contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, and it also lacks an in-frame exon but contains a differerent in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AI984397, AL050318, BC108706, BC153874
    Consensus CDS
    CCDS13275.1
    UniProtKB/Swiss-Prot
    Q9Y2H0
    Related
    ENSP00000345700.4, ENST00000340491.8
    Conserved Domains (1) summary
    pfam03359
    Location:121453
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    36306339..36528633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528689.3XP_011526991.1  disks large-associated protein 4 isoform X1

    Conserved Domains (1) summary
    pfam03359
    Location:660920
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. XM_047440012.1XP_047295968.1  disks large-associated protein 4 isoform X3

  3. XM_047440011.1XP_047295967.1  disks large-associated protein 4 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    38027049..38252509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323195.1XP_054179170.1  disks large-associated protein 4 isoform X1

  2. XM_054323197.1XP_054179172.1  disks large-associated protein 4 isoform X3

  3. XM_054323196.1XP_054179171.1  disks large-associated protein 4 isoform X2