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Zfp90 zinc finger protein 90 [ Mus musculus (house mouse) ]

Gene ID: 22751, updated on 18-Apr-2024

Summary

Official Symbol
Zfp90provided by MGI
Official Full Name
zinc finger protein 90provided by MGI
Primary source
MGI:MGI:104786
See related
Ensembl:ENSMUSG00000031907 AllianceGenome:MGI:104786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NK10; Zfp64; Zfp83; KRAB17; mKIAA1954; 6430515L01Rik
Summary
Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of DNA binding activity; negative regulation of transcription, DNA-templated; and positive regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including heart; hemolymphoid system gland; lung; male reproductive system; and urinary system. Orthologous to human ZFP90 (ZFP90 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 6.3), CNS E14 (RPKM 6.0) and 23 other tissues See more
Orthologs
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Genomic context

Location:
8 D3; 8 53.14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107141929..107153575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106415295..106426943)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39238 Neighboring gene STARR-positive B cell enhancer mm9_chr8:108935799-108936099 Neighboring gene predicted gene, 34026 Neighboring gene STARR-positive B cell enhancer ABC_E3802 Neighboring gene STARR-seq mESC enhancer starr_22555 Neighboring gene predicted gene, 51545 Neighboring gene STARR-seq mESC enhancer starr_22556 Neighboring gene STARR-seq mESC enhancer starr_22558 Neighboring gene STARR-seq mESC enhancer starr_22559 Neighboring gene cadherin 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 90
Names
Nk10 expressed protein
zfp-90
zinc finger protein 83
zinc finger protein 90 homolog
zinc finger protein NK10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368328.1NP_001355257.1  zinc finger protein 90 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096
  2. NM_001368329.1NP_001355258.1  zinc finger protein 90 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096
    Conserved Domains (2) summary
    COG5048
    Location:189617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:516536
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001368330.1NP_001355259.1  zinc finger protein 90 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096
  4. NM_001368331.1NP_001355260.1  zinc finger protein 90 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096
  5. NM_011764.4NP_035894.1  zinc finger protein 90 isoform 2

    See identical proteins and their annotated locations for NP_035894.1

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096
    Consensus CDS
    CCDS22635.1
    UniProtKB/Swiss-Prot
    Q3U4J5, Q543I6, Q61967
    Related
    ENSMUSP00000034382.8, ENSMUST00000034382.8
    Conserved Domains (5) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:197625
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:536561
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107141929..107153575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530849.5XP_006530912.1  zinc finger protein 90 isoform X1

    See identical proteins and their annotated locations for XP_006530912.1

    Related
    ENSMUST00000211958.2
    Conserved Domains (2) summary
    COG5048
    Location:189617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:516536
    ZF_C2H2; C2H2 Zn finger [structural motif]