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Zfp57 zinc finger protein 57 [ Mus musculus (house mouse) ]

Gene ID: 22715, updated on 5-Jan-2023

Summary

Official Symbol
Zfp57provided by MGI
Official Full Name
zinc finger protein 57provided by MGI
Primary source
MGI:MGI:99204
See related
Ensembl:ENSMUSG00000036036 AllianceGenome:MGI:99204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G19; Zfp-57
Summary
Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in genetic imprinting; maintenance of DNA methylation; and regulation of genetic imprinting. Acts upstream of or within DNA methylation involved in embryo development; genetic imprinting; and negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and retina. Orthologous to human ZFP57 (ZFP57 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 66.8), CNS E14 (RPKM 62.8) and 8 other tissues See more
Orthologs
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Genomic context

See Zfp57 in Genome Data Viewer
Location:
17 B1; 17
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37307060..37326196)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (37001163..37010729)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 6, pseudogene Neighboring gene RIKEN cDNA 2410137M14 gene Neighboring gene histocompatibility 2, M region locus 4, pseudogene Neighboring gene histocompatibility 2, M region locus 5 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene gamma-aminobutyric acid (GABA) B receptor, 1 Neighboring gene olfactory receptor family 2 subfamily H member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013745.2NP_001013767.1  zinc finger protein 57 isoform 1

    See identical proteins and their annotated locations for NP_001013767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC052028, CF731693, CR956641
    Consensus CDS
    CCDS28733.1
    UniProtKB/Swiss-Prot
    Q6JPI1, Q8C6P8
    Related
    ENSMUSP00000065811.8, ENSMUST00000069250.14
    Conserved Domains (4) summary
    smart00349
    Location:1572
    KRAB; krueppel associated box
    COG5048
    Location:139309
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:92134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:169190
    zf-C2H2; Zinc finger, C2H2 type
  2. NM_001168501.1NP_001161973.1  zinc finger protein 57 isoform 1

    See identical proteins and their annotated locations for NP_001161973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AV579696, BC052028, CR956641
    Consensus CDS
    CCDS28733.1
    UniProtKB/Swiss-Prot
    Q6JPI1, Q8C6P8
    Related
    ENSMUSP00000134418.2, ENSMUST00000174524.8
    Conserved Domains (4) summary
    smart00349
    Location:1572
    KRAB; krueppel associated box
    COG5048
    Location:139309
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:92134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:169190
    zf-C2H2; Zinc finger, C2H2 type
  3. NM_001168502.1NP_001161974.1  zinc finger protein 57 isoform 2

    See identical proteins and their annotated locations for NP_001161974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs at the 5' end and uses an alternate, in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in a shorter isoform (2) missing three internal aa compared to isoform 1.
    Source sequence(s)
    AK139625, BC052028, CR956641
    Consensus CDS
    CCDS50106.1
    UniProtKB/Swiss-Prot
    Q8C6P8
    Related
    ENSMUSP00000087414.7, ENSMUST00000089968.13
    Conserved Domains (4) summary
    smart00349
    Location:1269
    KRAB; krueppel associated box
    COG5048
    Location:136306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:89131
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:166187
    zf-C2H2; Zinc finger, C2H2 type

RNA

  1. NR_033137.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs at the 5' end compared to variant 1, and contains an upstream ORF with a strong Kozak signal, which according to leaky scanning model could interfere with the translation of the downstream primary ORF. Translation from the upstream ORF will render this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, this variant transcript is sufficiently abundant to represent as a non-coding RefSeq record.
    Source sequence(s)
    AK143118, BC052028, CR956641

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37307060..37326196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160583.1XP_036016476.1  zinc finger protein 57 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:1269
    KRAB; krueppel associated box
    COG5048
    Location:136306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:89131
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:166187
    zf-C2H2; Zinc finger, C2H2 type
  2. XM_036160582.1XP_036016475.1  zinc finger protein 57 isoform X1

    UniProtKB/Swiss-Prot
    Q6JPI1
    Conserved Domains (4) summary
    smart00349
    Location:1572
    KRAB; krueppel associated box
    COG5048
    Location:139309
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:92134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:169190
    zf-C2H2; Zinc finger, C2H2 type
  3. XM_036160584.1XP_036016477.1  zinc finger protein 57 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:1269
    KRAB; krueppel associated box
    COG5048
    Location:136306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:89131
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:166187
    zf-C2H2; Zinc finger, C2H2 type

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_009559.2: Suppressed sequence

    Description
    NM_009559.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.