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Zfp27 zinc finger protein 27 [ Mus musculus (house mouse) ]

Gene ID: 22689, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp27provided by MGI
Official Full Name
zinc finger protein 27provided by MGI
Primary source
MGI:MGI:99174
See related
Ensembl:ENSMUSG00000062040 AllianceGenome:MGI:99174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mkr-4; Zfp-27; mszf76
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; pancreas; reproductive system; spleen; and urinary system. Orthologous to human ZNF585A (zinc finger protein 585A) and ZNF585B (zinc finger protein 585B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 3.7), whole brain E14.5 (RPKM 3.3) and 28 other tissues See more
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Genomic context

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See Zfp27 in Genome Data Viewer
Location:
7 B1; 7 17.26 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29592762..29605976, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29893331..29906569, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 940 Neighboring gene STARR-positive B cell enhancer ABC_E8836 Neighboring gene STARR-positive B cell enhancer ABC_E10434 Neighboring gene zinc finger protein 420 Neighboring gene STARR-seq mESC enhancer starr_18494 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene zinc finger protein 383 Neighboring gene STARR-seq mESC enhancer starr_18496 Neighboring gene zinc finger protein 74 Neighboring gene RIKEN cDNA C230062I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30738577-30738760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease. Wang Y, et al. J Cell Mol Med, 2023 Nov. PMID 37668106, Free PMC Article
  2. Specific and ubiquitous expression of different Zn finger protein genes in the mouse. Chowdhury K, et al. Nucleic Acids Res, 1988 Nov 11. PMID 3143103, Free PMC Article
  3. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.
    Title: Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 27
Names
protein mKR4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037707.1 → NP_001032796.1  zinc finger protein 27 isoform 1

    See identical proteins and their annotated locations for NP_001032796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AC149283, BY740816, BY776985
    Consensus CDS
    CCDS21076.1
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4
    Related
    ENSMUSP00000054012.9, ENSMUST00000053521.15
    Conserved Domains (5) summary
    COG5048
    Location:317 → 746
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:711 → 731
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:152 → 171
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2 → 37
    KRAB; KRAB box
    pfam13465
    Location:752 → 775
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001285797.1 → NP_001272726.1  zinc finger protein 27 isoform 1

    See identical proteins and their annotated locations for NP_001272726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AI854840, AK135293
    Consensus CDS
    CCDS21076.1
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4
    Related
    ENSMUSP00000123953.2, ENSMUST00000162592.8
    Conserved Domains (5) summary
    COG5048
    Location:317 → 746
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:711 → 731
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:152 → 171
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2 → 37
    KRAB; KRAB box
    pfam13465
    Location:752 → 775
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001285798.1 → NP_001272727.1  zinc finger protein 27 isoform 1

    See identical proteins and their annotated locations for NP_001272727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AI854840, AK028500, AK135293
    Consensus CDS
    CCDS21076.1
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4
    Conserved Domains (5) summary
    COG5048
    Location:317 → 746
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:711 → 731
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:152 → 171
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2 → 37
    KRAB; KRAB box
    pfam13465
    Location:752 → 775
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001421813.1 → NP_001408742.1  zinc finger protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC149283
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4
    Related
    ENSMUSP00000125232.2, ENSMUST00000159920.2

  5. NM_001421814.1 → NP_001408743.1  zinc finger protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC149283
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4

  6. NM_001421815.1 → NP_001408744.1  zinc finger protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC149283
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4

  7. NM_001421816.1 → NP_001408745.1  zinc finger protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC149283
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4

  8. NM_001421817.1 → NP_001408746.1  zinc finger protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC149283
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4

  9. NM_001421818.1 → NP_001408747.1  zinc finger protein 27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149283

  10. NM_011754.2 → NP_035884.2  zinc finger protein 27 isoform 1

    See identical proteins and their annotated locations for NP_035884.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AC149283, BB611831, BY776985
    Consensus CDS
    CCDS21076.1
    UniProtKB/Swiss-Prot
    P10077, Q6PCZ6, Q8CED4
    Related
    ENSMUSP00000124684.2, ENSMUST00000161904.8
    Conserved Domains (5) summary
    COG5048
    Location:317 → 746
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:711 → 731
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:152 → 171
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2 → 37
    KRAB; KRAB box
    pfam13465
    Location:752 → 775
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29592762..29605976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242389.2 → XP_030098249.1  zinc finger protein 27 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:2 → 56
    KRAB; krueppel associated box
    COG5048
    Location:241 → 670
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:635 → 655
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:76 → 95
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:676 → 699
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10077.2 GenPept UniProtKB/Swiss-Prot:P10077

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