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FGR FGR proto-oncogene, Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 2268, updated on 17-Jun-2019

Summary

Official Symbol
FGRprovided by HGNC
Official Full Name
FGR proto-oncogene, Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:3697
See related
Ensembl:ENSG00000000938 MIM:164940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRC2; c-fgr; c-src2; p55-Fgr; p58-Fgr; p55c-fgr; p58c-fgr
Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 57.8), spleen (RPKM 29.9) and 6 other tissues See more
Orthologs

Genomic context

See FGR in Genome Data Viewer
Location:
1p35.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (27612064..27635561, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27938800..27961727, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376892 Neighboring gene AT-hook DNA binding motif containing 1 Neighboring gene uncharacterized LOC729973 Neighboring gene long intergenic non-protein coding RNA 2574

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR) in human B cells PubMed
env HIV-1 gp120-treated vaginal epithelial cells show upregulation of feline Gardner-Rasheed sarcoma viral oncogene homolog (FGR) expression as compared to untreated control PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43153, MGC75096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Fc-gamma receptor I complex binding IDA
Inferred from Direct Assay
more info
PubMed 
immunoglobulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphotyrosine residue binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
bone mineralization IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
immune response-regulating cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mast cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
response to virus TAS
Traceable Author Statement
more info
PubMed 
skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
aggresome IDA
Inferred from Direct Assay
more info
 
colocalizes_with cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein kinase Fgr
Names
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
c-fgr protooncogene
c-src-2 proto-oncogene
feline Gardner-Rasheed sarcoma viral oncogene homolog
p55-c-fgr protein
proto-oncogene c-Fgr
proto-oncogene tyrosine-protein kinase FGR
v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
NP_001036194.1
NP_001036212.1
NP_005239.1
XP_006710515.1
XP_011539312.1
XP_011539313.1
XP_011539314.1
XP_011539315.1
XP_011539316.1
XP_016856162.1
XP_016856163.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042729.2NP_001036194.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_001036194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) initiates at exon A, resulting in a distinct 5' UTR compared to variant 1. Expression of this variant is upregulated by Epstein-Barr virus. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AL031729, BC064382, BQ448283, DA960178, M27454
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    P09769
    UniProtKB/TrEMBL
    P78453
    Related
    ENSP00000363115.3, ENST00000374003.7
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267514
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001042747.1NP_001036212.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_001036212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) initiates at exon M3, resulting in a distinct 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    BC064382, BI771758, BQ448283, BX495937, DA952771
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    P09769
    Related
    ENSP00000382126.1, ENST00000399173.5
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267514
    PKc_like; Protein Kinases, catalytic domain
  3. NM_005248.3NP_005239.1  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_005239.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) initiates at exon M4 and represents the longest transcript. It is expressed in myelomonocytic cells. Variants 1, 2, and 3 encode the same isoform.
    Source sequence(s)
    AL031729, BC064382, BQ448283, DA139476
    Consensus CDS
    CCDS305.1
    UniProtKB/Swiss-Prot
    P09769
    Related
    ENSP00000363117.3, ENST00000374005.8
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267514
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    27612064..27635561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541010.1XP_011539312.1  tyrosine-protein kinase Fgr isoform X1

    See identical proteins and their annotated locations for XP_011539312.1

    UniProtKB/Swiss-Prot
    P09769
    Related
    ENSP00000363116.1, ENST00000374004.5
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267514
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017000674.1XP_016856163.1  tyrosine-protein kinase Fgr isoform X5

    Conserved Domains (3) summary
    pfam07714
    Location:59308
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:136
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:63310
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011541011.2XP_011539313.1  tyrosine-protein kinase Fgr isoform X2

    Conserved Domains (3) summary
    pfam07714
    Location:194443
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:108171
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:198445
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011541012.2XP_011539314.1  tyrosine-protein kinase Fgr isoform X3

    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267368
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017000673.1XP_016856162.1  tyrosine-protein kinase Fgr isoform X5

    Conserved Domains (3) summary
    pfam07714
    Location:59308
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:136
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:63310
    PKc_like; Protein Kinases, catalytic domain
  6. XM_006710452.2XP_006710515.1  tyrosine-protein kinase Fgr isoform X1

    See identical proteins and their annotated locations for XP_006710515.1

    UniProtKB/Swiss-Prot
    P09769
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80137
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267514
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011541014.3XP_011539316.1  tyrosine-protein kinase Fgr isoform X5

    Conserved Domains (3) summary
    pfam07714
    Location:59308
    Pkinase_Tyr; Protein tyrosine kinase
    cl15255
    Location:136
    SH2; Src homology 2 (SH2) domain
    cl21453
    Location:63310
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011541013.3XP_011539315.1  tyrosine-protein kinase Fgr isoform X4

    Related
    ENSP00000407670.1, ENST00000457296.5
    Conserved Domains (3) summary
    cd10367
    Location:140240
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:80135
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:267339
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_946583.3 RNA Sequence

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