U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fgr FGR proto-oncogene, Src family tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 14191, updated on 2-Nov-2024

Summary

Official Symbol
Fgrprovided by MGI
Official Full Name
FGR proto-oncogene, Src family tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:95527
See related
Ensembl:ENSMUSG00000028874 AllianceGenome:MGI:95527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ali18; Mhdaali18
Summary
Enables several functions, including immunoglobulin receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including defense response to Gram-positive bacterium; integrin-mediated signaling pathway; and regulation of vesicle-mediated transport. Acts upstream of or within bone mineralization and skeletal system morphogenesis. Located in plasma membrane. Colocalizes with actin cytoskeleton and ruffle membrane. Is expressed in 2-cell stage embryo; blastocyst; metanephros; nervous system; and neural ectoderm. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 12.8), lung adult (RPKM 4.7) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fgr in Genome Data Viewer
Location:
4 D2.3; 4 66.11 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132701406..132729204)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132974095..133001893)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 76, member A Neighboring gene STARR-positive B cell enhancer ABC_E2716 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132500014-132500167 Neighboring gene STARR-positive B cell enhancer ABC_E9242 Neighboring gene predicted gene, 36518 Neighboring gene STARR-seq mESC enhancer starr_11587 Neighboring gene STARR-seq mESC enhancer starr_11589 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132531847-132532036 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132533610-132533847 Neighboring gene STARR-seq mESC enhancer starr_11591 Neighboring gene predicted gene, 36599 Neighboring gene AT hook, DNA binding motif, containing 1 Neighboring gene STARR-seq mESC enhancer starr_11597 Neighboring gene STARR-seq mESC enhancer starr_11602 Neighboring gene STARR-seq mESC enhancer starr_11605

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables Fc-gamma receptor I complex binding IEA
Inferred from Electronic Annotation
more info
 
enables Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
 
enables immunoglobulin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of natural killer cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in aggresome IEA
Inferred from Electronic Annotation
more info
 
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase Fgr
Names
Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
p55-Fgr
proto-oncogene c-Fgr
proto-oncogene tyrosine-protein kinase Fgr
NP_034338.3
XP_006538607.1
XP_006538608.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010208.4NP_034338.3  tyrosine-protein kinase Fgr

    See identical proteins and their annotated locations for NP_034338.3

    Status: VALIDATED

    Source sequence(s)
    AI661913, AK038141, AK155902, BY204076
    Consensus CDS
    CCDS18739.1
    UniProtKB/Swiss-Prot
    P14234, Q61404, Q8BGM0
    UniProtKB/TrEMBL
    Q6GTF2
    Related
    ENSMUSP00000030693.7, ENSMUST00000030693.13
    Conserved Domains (3) summary
    cd10367
    Location:128228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255502
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132701406..132729204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538544.5XP_006538607.1  tyrosine-protein kinase Fgr isoform X1

    See identical proteins and their annotated locations for XP_006538607.1

    UniProtKB/Swiss-Prot
    P14234, Q61404, Q8BGM0
    UniProtKB/TrEMBL
    Q6GTF2
    Conserved Domains (3) summary
    cd10367
    Location:128228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255502
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006538545.5XP_006538608.1  tyrosine-protein kinase Fgr isoform X1

    See identical proteins and their annotated locations for XP_006538608.1

    UniProtKB/Swiss-Prot
    P14234, Q61404, Q8BGM0
    UniProtKB/TrEMBL
    Q6GTF2
    Related
    ENSMUSP00000128411.2, ENSMUST00000171223.2
    Conserved Domains (3) summary
    cd10367
    Location:128228
    SH2_Src_Fgr; Src homology 2 (SH2) domain found in Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, Fgr
    cl17036
    Location:68125
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:255502
    PKc_like; Protein Kinases, catalytic domain