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Zfp148 zinc finger protein 148 [ Mus musculus (house mouse) ]

Gene ID: 22661, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp148provided by MGI
Official Full Name
zinc finger protein 148provided by MGI
Primary source
MGI:MGI:1332234
See related
Ensembl:ENSMUSG00000022811 AllianceGenome:MGI:1332234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BERF-1; BFCOL1; ZBP-89; Znf148; 2210405J08Rik
Summary
Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within gamete generation and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system. Orthologous to human ZNF148 (zinc finger protein 148). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 4.4), cortex adult (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp148 in Genome Data Viewer
Location:
16 B3; 16 23.93 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33201145..33324273)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33380775..33503903)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8629 Neighboring gene sorting nexin 4 Neighboring gene STARR-seq mESC enhancer starr_40689 Neighboring gene STARR-seq mESC enhancer starr_40691 Neighboring gene STARR-seq mESC enhancer starr_40692 Neighboring gene RIKEN cDNA 1700007L15 gene Neighboring gene STARR-seq mESC enhancer starr_40693 Neighboring gene STARR-seq mESC enhancer starr_40697 Neighboring gene STARR-seq mESC enhancer starr_40698 Neighboring gene STARR-seq mESC enhancer starr_40700 Neighboring gene solute carrier family 12 (potassium/chloride transporters), member 8 Neighboring gene STARR-seq mESC enhancer starr_40702 Neighboring gene STARR-positive B cell enhancer ABC_E5537 Neighboring gene STARR-seq mESC enhancer starr_40703 Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E11611

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The transcriptional repressor ZBP-89 and the lack of Sp1/Sp3, c-Jun and Stat3 are important for the down-regulation of the vimentin gene during C2C12 myogenesis. Salmon M, et al. Differentiation, 2009 Jun. PMID 19505630, Free PMC Article
  2. β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses. Emfinger CH, et al. JCI Insight, 2022 May 23. PMID 35603790, Free PMC Article
  3. Conserved structure and promoter sequence similarity in the mouse and human genes encoding the zinc finger factor BERF-1/BFCOL1/ZBP-89. Feo S, et al. Biochem Biophys Res Commun, 2001 Apr 27. PMID 11322790
  4. Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89. Li X, et al. Stem Cells, 2014 Mar. PMID 24549639, Free PMC Article
  5. Negative regulation of beta enolase gene transcription in embryonic muscle is dependent upon a zinc finger factor that binds to the G-rich box within the muscle-specific enhancer. Passantino R, et al. J Biol Chem, 1998 Jan 2. PMID 9417107

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zfp281 and Zfp148 control CD4[+] T cell thymic development and TH2 functions.
    Title: Zfp281 and Zfp148 control CD4(+) T cell thymic development and T(H)2 functions.
  2. Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in regulating HaCaT cell proliferation, migration and apoptosis.
    Title: Identification of the MALAT1/miR-106a-5p/ZNF148 feedback loop in regulating HaCaT cell proliferation, migration and apoptosis.
  3. beta Cell-specific deletion of Zfp148 improves nutrient-stimulated beta cell Ca2+ responses.
    Title: β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses.
  4. Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway.
    Title: Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway.
  5. ZFP148 is important in the regulation of proliferation, smooth muscle gene downregulation, and apoptosis in aneurysm development.
    Title: ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Neurofibromin 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation.
  6. Data indicate zinc finger protein 148 (ZFP148) as a transcription factor that differentially binds to the zinc finger protein 30 protein (Zfp30) promoter region harboring rs51434084.
    Title: Differential Regulation of Zfp30 Expression in Murine Airway Epithelia Through Altered Binding of ZFP148 to rs51434084.
  7. The results suggest that Zfp148 controls the fate of newly transformed intestinal tumor cells by repressing p53 and that targeting Zfp148 might be useful in the treatment of colorectal cancer.
    Title: Targeting Zfp148 activates p53 and reduces tumor initiation in the gut.
  8. Zfp148 deficiency increases p53 activity and protects against atherosclerosis by causing proliferation arrest of lesional macrophages.
    Title: Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53.
  9. These data identify an important role for ZBP-89 in regulating stress hematopoiesis in adult mouse bone marrow.
    Title: Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.
  10. Results indicate that Zfp148-deficient mice generate normal mature hematopoietic populations.
    Title: Zinc finger protein 148 is dispensable for primitive and definitive hematopoiesis in mice.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 148
Names
G-rich box-binding protein
beta enolase repressor factor 1
transcription factor BFCOL1
transcription factor ZBP-89
zinc finger DNA-binding protein 89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358569.1 → NP_001345498.1  zinc finger protein 148

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC122247, AC127412
    Consensus CDS
    CCDS28130.1
    UniProtKB/Swiss-Prot
    P97475, Q61624
    UniProtKB/TrEMBL
    Q3UJ69, Q548L0
    Related
    ENSMUSP00000087106.7, ENSMUST00000089677.7
    Conserved Domains (3) summary
    sd00017
    Location:173 → 193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:171 → 193
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:214 → 238
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001358570.1 → NP_001345499.1  zinc finger protein 148

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC122247, AC127412
    Consensus CDS
    CCDS28130.1
    UniProtKB/Swiss-Prot
    P97475, Q61624
    UniProtKB/TrEMBL
    Q3UJ69, Q548L0
    Conserved Domains (3) summary
    sd00017
    Location:173 → 193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:171 → 193
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:214 → 238
    zf-H2C2_2; Zinc-finger double domain

  3. NM_011749.4 → NP_035879.1  zinc finger protein 148

    See identical proteins and their annotated locations for NP_035879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC127412, AK146591, CJ129103, CK634070
    Consensus CDS
    CCDS28130.1
    UniProtKB/Swiss-Prot
    P97475, Q61624
    UniProtKB/TrEMBL
    Q3UJ69, Q548L0
    Related
    ENSMUSP00000126338.2, ENSMUST00000165418.9
    Conserved Domains (3) summary
    sd00017
    Location:173 → 193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:171 → 193
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:214 → 238
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    33201145..33324273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522103.5 → XP_006522166.1  zinc finger protein 148 isoform X3

    UniProtKB/TrEMBL
    A0A338P6K3, Q3UJ69
    Related
    ENSMUSP00000156030.2, ENSMUST00000232023.2
    Conserved Domains (3) summary
    sd00017
    Location:131 → 151
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:129 → 151
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:172 → 196
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006522098.4 → XP_006522161.1  zinc finger protein 148 isoform X1

    See identical proteins and their annotated locations for XP_006522161.1

    UniProtKB/TrEMBL
    Q3UJ69
    Conserved Domains (3) summary
    sd00017
    Location:179 → 199
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:177 → 199
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:220 → 244
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036159911.1 → XP_036015804.1  zinc finger protein 148 isoform X2

    UniProtKB/Swiss-Prot
    P97475, Q61624
    UniProtKB/TrEMBL
    Q3UJ69, Q548L0
    Conserved Domains (3) summary
    sd00017
    Location:173 → 193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:171 → 193
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:214 → 238
    zf-H2C2_2; Zinc-finger double domain

  4. XM_006522099.5 → XP_006522162.1  zinc finger protein 148 isoform X1

    See identical proteins and their annotated locations for XP_006522162.1

    UniProtKB/TrEMBL
    Q3UJ69
    Conserved Domains (3) summary
    sd00017
    Location:179 → 199
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:177 → 199
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:220 → 244
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011245888.3 → XP_011244190.1  zinc finger protein 148 isoform X1

    See identical proteins and their annotated locations for XP_011244190.1

    UniProtKB/TrEMBL
    Q3UJ69
    Conserved Domains (3) summary
    sd00017
    Location:179 → 199
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:177 → 199
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:220 → 244
    zf-H2C2_2; Zinc-finger double domain

  6. XM_006522100.5 → XP_006522163.1  zinc finger protein 148 isoform X1

    See identical proteins and their annotated locations for XP_006522163.1

    UniProtKB/TrEMBL
    Q3UJ69
    Conserved Domains (3) summary
    sd00017
    Location:179 → 199
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:177 → 199
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:220 → 244
    zf-H2C2_2; Zinc-finger double domain

  7. XM_006522101.5 → XP_006522164.1  zinc finger protein 148 isoform X1

    See identical proteins and their annotated locations for XP_006522164.1

    UniProtKB/TrEMBL
    Q3UJ69
    Conserved Domains (3) summary
    sd00017
    Location:179 → 199
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:177 → 199
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:220 → 244
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61624.2 GenPept UniProtKB/Swiss-Prot:Q61624

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