Format

Send to:

Choose Destination

ZNF148 zinc finger protein 148 [ Homo sapiens (human) ]

Gene ID: 7707, updated on 7-Jun-2020

Summary

Official Symbol
ZNF148provided by HGNC
Official Full Name
zinc finger protein 148provided by HGNC
Primary source
HGNC:HGNC:12933
See related
Ensembl:ENSG00000163848 MIM:601897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BERF-1; BFCOL1; GDACCF; ZBP-89; ZFP148; pHZ-52; HT-BETA
Summary
The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]
Expression
Ubiquitous expression in thyroid (RPKM 14.7), ovary (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See ZNF148 in Genome Data Viewer
Location:
3q21.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (125225669..125375354, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (124944513..125094198, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 8 Neighboring gene RNA, U6 small nuclear 230, pseudogene Neighboring gene microRNA 5092 Neighboring gene deoxyuridine triphosphatase pseudogene 1 Neighboring gene DNAJB6 pseudogene 7 Neighboring gene uncharacterized LOC105374080 Neighboring gene RNA, U6 small nuclear 232, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 148 (ZNF148) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686L18248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 148
Names
CACCC box-binding protein
CLL-associated antigen KW-10
transcription factor ZBP-89
zinc finger DNA-binding protein 89

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052987.1 RefSeqGene

    Range
    5001..154686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348424.1NP_001335353.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AC108688
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001348425.2NP_001335354.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, BC050260, DA726996
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Related
    ENSP00000420448.1, ENST00000485866.5
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001348426.2NP_001335355.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, BM917104, BQ441085, N27696
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001348427.2NP_001335356.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, AU121036, BM917104, BP237604, DA225087
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001348428.2NP_001335357.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, AU121036, BM917104, BP237604, DA780458, DB145818
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001348429.2NP_001335358.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, BQ441085, BU178504
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001348430.2NP_001335359.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, AF432210, BQ674550
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Related
    ENSP00000420335.1, ENST00000484491.5
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001348431.2NP_001335360.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, BQ441085, BU178504, CR980884
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Related
    ENSP00000419322.1, ENST00000492394.5
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001348432.2NP_001335361.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, BQ441085, BU178504, DA780458
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001348433.2NP_001335362.1  zinc finger protein 148 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AA481164, AC108688, BP378362, BU178504, BU941780, CV571288
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain
  11. NM_001348434.2NP_001335363.1  zinc finger protein 148 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AA481164, AC108688, AU121036, BM917104, DA492993
    Conserved Domains (3) summary
    sd00017
    Location:131151
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:129151
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:172196
    zf-H2C2_2; Zinc-finger double domain
  12. NM_001348436.2NP_001335365.1  zinc finger protein 148 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC108688, BC050260, DA726996, GD148926
    Conserved Domains (3) summary
    COG5048
    Location:166231
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:185210
    zf-H2C2_2; Zinc-finger double domain
  13. NM_021964.3NP_068799.2  zinc finger protein 148 isoform a

    See identical proteins and their annotated locations for NP_068799.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
    Source sequence(s)
    AC108688
    Consensus CDS
    CCDS3031.1
    UniProtKB/Swiss-Prot
    Q9UQR1
    Related
    ENSP00000353863.4, ENST00000360647.8
    Conserved Domains (2) summary
    sd00017
    Location:173193
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:214238
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    125225669..125375354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center