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Rab29 RAB29, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 226422, updated on 21-May-2024

Summary

Official Symbol
Rab29provided by MGI
Official Full Name
RAB29, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:2385107
See related
Ensembl:ENSMUSG00000026433 AllianceGenome:MGI:2385107
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab7l1
Summary
Enables GTP binding activity. Involved in cilium assembly and protein localization to ciliary membrane. Acts upstream of or within Golgi organization. Located in Golgi apparatus and vesicle. Orthologous to human RAB29 (RAB29, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 9.9), subcutaneous fat pad adult (RPKM 7.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rab29 in Genome Data Viewer
Location:
1 E4; 1 57.21 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131795004..131801003)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131867210..131872887)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene peptidase M20 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02225 Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene solute carrier family 41, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E5799 Neighboring gene STARR-seq mESC enhancer starr_02227 Neighboring gene STARR-seq mESC enhancer starr_02228 Neighboring gene STARR-seq mESC enhancer starr_02229 Neighboring gene nuclear casein kinase and cyclin-dependent kinase substrate 1 Neighboring gene solute carrier family 45, member 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:133879500-133879800

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC28972, MGC36539

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in melanosome organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to ciliary membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of retrograde transport, endosome to Golgi NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in vacuole ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-7L1
Names
RAB7, member RAS oncogene family-like 1
rab-7-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421410.1NP_001408339.1  ras-related protein Rab-7L1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161805
    UniProtKB/TrEMBL
    E9QLQ7
    Related
    ENSMUSP00000108005.2, ENSMUST00000112386.8
  2. NM_001421411.1NP_001408340.1  ras-related protein Rab-7L1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC161805
  3. NM_001421412.1NP_001408341.1  ras-related protein Rab-7L1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161805
  4. NM_001421413.1NP_001408342.1  ras-related protein Rab-7L1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC161805
  5. NM_001421414.1NP_001408343.1  ras-related protein Rab-7L1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC161805
    UniProtKB/TrEMBL
    E9QLQ7
  6. NM_144875.3NP_659124.2  ras-related protein Rab-7L1 isoform 1

    See identical proteins and their annotated locations for NP_659124.2

    Status: VALIDATED

    Source sequence(s)
    AC161805
    Consensus CDS
    CCDS15276.1
    UniProtKB/TrEMBL
    E9QLQ7
    Related
    ENSMUSP00000027693.8, ENSMUST00000027693.8
    Conserved Domains (2) summary
    smart00175
    Location:8176
    RAB; Rab subfamily of small GTPases
    cd04107
    Location:8204
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

RNA

  1. NR_185300.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161805
  2. NR_185301.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC161805

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131795004..131801003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)