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RAB29 RAB29, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 8934, updated on 5-Jul-2021

Summary

Official Symbol
RAB29provided by HGNC
Official Full Name
RAB29, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9789
See related
Ensembl:ENSG00000117280 MIM:603949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB7L; RAB7L1
Expression
Broad expression in kidney (RPKM 27.5), thyroid (RPKM 17.1) and 24 other tissues See more
Orthologs
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Genomic context

See RAB29 in Genome Data Viewer
Location:
1q32.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (205767986..205775487, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205737114..205744610, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 45 member 3 Neighboring gene uncharacterized LOC105371701 Neighboring gene nuclear casein kinase and cyclin dependent kinase substrate 1 Neighboring gene uncharacterized LOC105371702 Neighboring gene solute carrier family 41 member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686P1051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in melanosome organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in viral RNA genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in intracellular vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
located_in vacuole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-7L1
Names
RAB7, member RAS oncogene family-like 1
rab-7-like protein 1
ras-related protein Rab-29

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135662.2NP_001129134.1  ras-related protein Rab-7L1 isoform 1

    See identical proteins and their annotated locations for NP_001129134.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC119673, AK313000, CF528995, DA284582
    Consensus CDS
    CCDS1459.1
    UniProtKB/Swiss-Prot
    O14966
    UniProtKB/TrEMBL
    B2R7I9, Q6FGU7
    Related
    ENSP00000235932.4, ENST00000235932.8
    Conserved Domains (1) summary
    cd04107
    Location:8203
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
  2. NM_001135663.2NP_001129135.1  ras-related protein Rab-7L1 isoform 2

    See identical proteins and their annotated locations for NP_001129135.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional segment in the 5' UTR and lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 2.
    Source sequence(s)
    AC119673, AK303879, CF528995, DA284582, DC314882
    Consensus CDS
    CCDS44301.1
    UniProtKB/Swiss-Prot
    O14966
    Related
    ENSP00000389899.2, ENST00000446390.6
    Conserved Domains (1) summary
    cd04107
    Location:8179
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
  3. NM_001135664.2NP_001129136.1  ras-related protein Rab-7L1 isoform 3

    See identical proteins and their annotated locations for NP_001129136.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC119673, CF528995, DA284582, DA377295
    Consensus CDS
    CCDS44302.1
    UniProtKB/Swiss-Prot
    O14966
    Related
    ENSP00000416613.2, ENST00000437324.6
    Conserved Domains (1) summary
    cl38936
    Location:1131
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_003929.3NP_003920.1  ras-related protein Rab-7L1 isoform 1

    See identical proteins and their annotated locations for NP_003920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC119673, BX647960, CF528995, DA284582, DC365059
    Consensus CDS
    CCDS1459.1
    UniProtKB/Swiss-Prot
    O14966
    UniProtKB/TrEMBL
    Q6FGU7
    Related
    ENSP00000356107.3, ENST00000367139.8
    Conserved Domains (1) summary
    cd04107
    Location:8203
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    205767986..205775487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245571.1XP_005245628.1  ras-related protein Rab-7L1 isoform X1

    See identical proteins and their annotated locations for XP_005245628.1

    UniProtKB/Swiss-Prot
    O14966
    UniProtKB/TrEMBL
    Q6FGU7
    Conserved Domains (1) summary
    cd04107
    Location:8203
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
  2. XM_006711605.3XP_006711668.1  ras-related protein Rab-7L1 isoform X3

    See identical proteins and their annotated locations for XP_006711668.1

    UniProtKB/Swiss-Prot
    O14966
    Conserved Domains (1) summary
    cl38936
    Location:1131
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_005245569.1XP_005245626.1  ras-related protein Rab-7L1 isoform X1

    See identical proteins and their annotated locations for XP_005245626.1

    UniProtKB/Swiss-Prot
    O14966
    UniProtKB/TrEMBL
    Q6FGU7
    Conserved Domains (1) summary
    cd04107
    Location:8203
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
  4. XM_006711606.3XP_006711669.1  ras-related protein Rab-7L1 isoform X3

    See identical proteins and their annotated locations for XP_006711669.1

    UniProtKB/Swiss-Prot
    O14966
    Conserved Domains (1) summary
    cl38936
    Location:1131
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_017002750.1XP_016858239.1  ras-related protein Rab-7L1 isoform X2

    UniProtKB/Swiss-Prot
    O14966
    Conserved Domains (1) summary
    cd04107
    Location:8179
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
  6. XM_017002748.1XP_016858237.1  ras-related protein Rab-7L1 isoform X2

    UniProtKB/Swiss-Prot
    O14966
    Conserved Domains (1) summary
    cd04107
    Location:8179
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
  7. XM_017002749.1XP_016858238.1  ras-related protein Rab-7L1 isoform X2

    UniProtKB/Swiss-Prot
    O14966
    Conserved Domains (1) summary
    cd04107
    Location:8179
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
  8. XM_005245570.1XP_005245627.1  ras-related protein Rab-7L1 isoform X1

    See identical proteins and their annotated locations for XP_005245627.1

    UniProtKB/Swiss-Prot
    O14966
    UniProtKB/TrEMBL
    Q6FGU7
    Conserved Domains (1) summary
    cd04107
    Location:8203
    Rab32_Rab38; Rab GTPase families 18 (Rab18) and 32 (Rab32)
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