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FGF13 fibroblast growth factor 13 [ Homo sapiens (human) ]

Gene ID: 2258, updated on 5-Jul-2025
Official Symbol
FGF13provided by HGNC
Official Full Name
fibroblast growth factor 13provided by HGNC
Primary source
HGNC:HGNC:3670
See related
Ensembl:ENSG00000129682 MIM:300070; AllianceGenome:HGNC:3670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FGF2; FHF2; DEE90; FHF-2; FGF-13; XLID110; LINC00889
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]
Expression
Broad expression in brain (RPKM 11.3), fat (RPKM 6.2) and 21 other tissues See more
Orthologs
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See FGF13 in Genome Data Viewer
Location:
Xq26.3-q27.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (138614727..139205023, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (136925164..137515927, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (137696888..138287185, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene keratin 8 pseudogene 6 Neighboring gene H2A.Q variant histone 1, pseudogene Neighboring gene microRNA 504 Neighboring gene FGF13 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chrX:137842490-137843019 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:137859976-137861175 Neighboring gene tropomyosin 2 pseudogene Neighboring gene NFE2L2 motif-containing MPRA enhancer 215 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:138226529-138226732 Neighboring gene uncharacterized LOC124905222 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:138306638-138307247 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:138307248-138307856 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:138423703-138424360 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:138424361-138425018 Neighboring gene SNRPN upstream open reading frame like (pseudogene) Neighboring gene steroid 5 alpha-reductase 1 pseudogene 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Associated conditions

Description Tests
Developmental and epileptic encephalopathy, 90
MedGen: C5542345 OMIM: 301058 GeneReviews: Not available
Compare labs
Intellectual developmental disorder, X-linked 110
MedGen: C5774180 OMIM: 301095 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ30672, FLJ30820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
enables beta-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity TAS
Traceable Author Statement
more info
PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables sodium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of a nerve IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cerebral cortex cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebral cortex cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of neuroblast polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inhibitory synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in inhibitory synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in learning IEA
Inferred from Electronic Annotation
more info
 
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within learning or memory IEA
Inferred from Electronic Annotation
more info
 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of collateral sprouting ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neurogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of voltage-gated sodium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intercalated disc IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
fibroblast growth factor 13
Names
fibroblast growth factor homologous factor 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001139498.2NP_001132970.1  fibroblast growth factor 13 isoform 4

    See identical proteins and their annotated locations for NP_001132970.1

    Status: REVIEWED

    Source sequence(s)
    AL031386, AL357123, Z81007, Z82193
    Consensus CDS
    CCDS55512.1
    UniProtKB/Swiss-Prot
    Q92913
    Related
    ENSP00000487411.1, ENST00000626909.2
    Conserved Domains (1) summary
    smart00442
    Location:21151
    FGF; Acidic and basic fibroblast growth factor family
  2. NM_001139500.2NP_001132972.1  fibroblast growth factor 13 isoform 2

    See identical proteins and their annotated locations for NP_001132972.1

    Status: REVIEWED

    Source sequence(s)
    AL031386, AL357123, Z81007, Z82193, Z82204
    Consensus CDS
    CCDS55513.1
    Related
    ENSP00000396198.2, ENST00000436198.6
    Conserved Domains (1) summary
    smart00442
    Location:77207
    FGF; Acidic and basic fibroblast growth factor family
  3. NM_001139501.2NP_001132973.1  fibroblast growth factor 13 isoform 3

    See identical proteins and their annotated locations for NP_001132973.1

    Status: REVIEWED

    Source sequence(s)
    AL023800, AL031386, AL357123, Z81007, Z82193, Z82204
    Consensus CDS
    CCDS55511.1
    Related
    ENSP00000409276.2, ENST00000441825.8
    Conserved Domains (1) summary
    smart00442
    Location:48178
    FGF; Acidic and basic fibroblast growth factor family
  4. NM_001139502.2NP_001132974.1  fibroblast growth factor 13 isoform 3

    See identical proteins and their annotated locations for NP_001132974.1

    Status: REVIEWED

    Source sequence(s)
    AL031386, AL357123, Z82193, Z82204
    Consensus CDS
    CCDS55511.1
    Conserved Domains (1) summary
    smart00442
    Location:48178
    FGF; Acidic and basic fibroblast growth factor family
  5. NM_004114.5NP_004105.1  fibroblast growth factor 13 isoform 1

    See identical proteins and their annotated locations for NP_004105.1

    Status: REVIEWED

    Source sequence(s)
    AL031386, AL357123, Z82193
    Consensus CDS
    CCDS14665.1
    UniProtKB/Swiss-Prot
    B1AK18, B7Z4M7, B7Z8N0, D3DWH4, O95830, Q92913, Q9NZH9, Q9NZI0
    UniProtKB/TrEMBL
    A8K1P5
    Related
    ENSP00000322390.6, ENST00000315930.11
    Conserved Domains (1) summary
    smart00442
    Location:67197
    FGF; Acidic and basic fibroblast growth factor family
  6. NM_033642.3NP_378668.1  fibroblast growth factor 13 isoform 5

    See identical proteins and their annotated locations for NP_378668.1

    Status: REVIEWED

    Source sequence(s)
    AL031386, AL357123, Z82193
    Consensus CDS
    CCDS14664.1
    UniProtKB/Swiss-Prot
    Q92913
    Related
    ENSP00000303391.4, ENST00000305414.9
    Conserved Domains (1) summary
    smart00442
    Location:14144
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    138614727..139205023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    136925164..137515927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326696.1XP_054182671.1  fibroblast growth factor 13 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_026935.1: Suppressed sequence

    Description
    NR_026935.1: This RefSeq was removed because the gene was discontinued.