1QQK,2P23


Conserved Protein Domain Family
FGF

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smart00442: FGF 
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Acidic and basic fibroblast growth factor family.
Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities.
Statistics
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PSSM-Id: 214665
Aligned: 24 rows
Threshold Bit Score: 130.843
Threshold Setting Gi: 2979530
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1QQK_A         9 DIRVRRLFCRTq-----WYLRIDKR--GKVKGTQEMRNSYNIMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKE--- 78  Norway rat
P91672       247 TSRKIQLYIKN------RILQILRD--GVVNGTQDENSEFTILQRSTVDVGRIKLQSVATCLYLCMDACGVPYGSKD--- 315 fruit fly
O95750        41 PIRLRHLYTSGphglssCFLRIRAD--GVVDCARGQ-SAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQy-- 115 human
O73554        25 TRRQIQMFVKN------QYIAVDGN--GDVMGCRDRTASRTVFYRISISHNLLSLVNSVSCRYVCINACGYVYTLAMnga 96  Spodoptera litt...
Q9YMH2        21 TGRLVQIGINR------QLLTCFAN--GTVGGSTDERADGTAWRRWAAKPREVLIRSAATCAFVCLDDCGFLYTAAEa-- 90  Lymantria dispa...
NP_054061     26 TSIPGQLFINR------QFLAVNPD--GAVYGTIESDNVDTIFKRVAVDRNRIVIQNAITCVYLCMDRCGQLYGSKT--- 94  AcMNPV
NP_046183     27 TQRLVQVLIHN------RYLAVRSD--GTVGGTTYASSLDTVLQRIAIAHGRILLRNAVSCMYVCLDRCGAMYASAA--- 95  OpMNPV
2P23_A        19 PIRLRHLYTSGphglssCFLRIRAD--GVVDCARGQ-SAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQ--- 92  human
NP_032029     49 ITRLQYLYSAGpyv-snCFLRIRSD--GSVDCEEDQ-NERNLLEFRAVALKTIAIKDVSSVRYLCMSADGKIYGLIR--- 121 house mouse
XP_002195877  50 lVRTYQLYSRTs----gKHVQILDNkkINAMAEDGDVHAKLIVETDTFG-SRVRIKGAATGFYICMNKKGKLIGKSNg-- 122 zebra finch
1QQK_A        79 --CN-EDCNFKELILENHYNTYASAKWTHsggEMFVALNQKGLPVKG----K--KTKKEQKTAHFLPM 137 Norway rat
P91672       316 --FT-DDCVFNENMGLQNYNTYSSTYHSQarrVFYLALNGSGQPRRT----QipASRSLGKLSTYTNA 376 fruit fly
O95750       116 --SE-EDCAFEEEIRPDGYNVYRSEKHR-----LPVSLSSAKQRQLY-------KNRGFLPLSHFLPM 168 human
O73554        97 ggIS-QDCLLREHMTESYYNWYYREDNDT---RSFLALNKYGRTKRV----RikSDDVLHNNINSINV 156 Spodoptera littoralis NPV
Q9YMH2        91 --PN-KECLFVEELSENHYSYLYRVHDRS---RIYLALGANGKSRRV----V--APVDEPLADHGNPT 146 Lymantria dispar MNPV
NP_054061     95 --LS-KDCFMREFLEKNNYNTYYKVYDRK---LTYVALKNDGTPRKL----QisKSRKLGKLSVYAMA 152 AcMNPV
NP_046183     96 --LS-SDCILNEVMLENNYDVMFKIYNGK---KTYVALDNTGNPRRVqlprQ--RPLRMMNVYTFIMR 155 OpMNPV
2P23_A        93 --YSeEDCAFEEEIRPDGYNVYRSEKHR-----LPVSLSSAKQRQLY-------KNRGFLPLSHFLPM 146 human
NP_032029    122 --YSeEDCTFREEMDCLGYNQYRSMKHH-----LHIIFIQAKPREQL----Q--DQKPSNFIPVFHRS 176 house mouse
XP_002195877 123 --KG-KDCVFTEIVLENNYTALQNAKYEG----WYMAFTRKGRPRKG----S--KTRQHQREVHFMKR 177 zebra finch
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