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Fgf13 fibroblast growth factor 13 [ Mus musculus (house mouse) ]

Gene ID: 14168, updated on 31-Dec-2019

Summary

Official Symbol
Fgf13provided by MGI
Official Full Name
fibroblast growth factor 13provided by MGI
Primary source
MGI:MGI:109178
See related
Ensembl:ENSMUSG00000031137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fhf2
Expression
Biased expression in CNS E18 (RPKM 22.7), frontal lobe adult (RPKM 16.1) and 11 other tissues See more
Orthologs

Genomic context

See Fgf13 in Genome Data Viewer
Location:
X A6; X 33.31 cM
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (59062139..59585572, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (56315327..56387613, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene RIKEN cDNA 4930550L24 gene Neighboring gene microRNA 504 Neighboring gene predicted gene, 36570 Neighboring gene U6 spliceosomal RNA Neighboring gene histidyl-tRNA synthetase 2, mitochondrial (putative) pseudogene Neighboring gene predicted gene, 39518 Neighboring gene predicted gene, 36631 Neighboring gene synaptophysin-like protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
NOT apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of neuroblast polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT establishment of neuroblast polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 13
Names
fibroblast growth factor homologous factor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290414.1NP_001277343.1  fibroblast growth factor 13 isoform 2

    See identical proteins and their annotated locations for NP_001277343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AL669891, AL670091, AL672247, AL713968
    Conserved Domains (1) summary
    smart00442
    Location:77207
    FGF; Acidic and basic fibroblast growth factor family
  2. NM_001290415.1NP_001277344.1  fibroblast growth factor 13 isoform 3

    See identical proteins and their annotated locations for NP_001277344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK141848, BC018238, CD776909, CJ064772
    Consensus CDS
    CCDS72383.1
    UniProtKB/Swiss-Prot
    P70377
    Related
    ENSMUSP00000113206.1, ENSMUST00000119306.1
    Conserved Domains (1) summary
    smart00442
    Location:14144
    FGF; Acidic and basic fibroblast growth factor family
  3. NM_001356335.1NP_001343264.1  fibroblast growth factor 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL669891, AL713968
    Conserved Domains (1) summary
    smart00442
    Location:21151
    FGF; Acidic and basic fibroblast growth factor family
  4. NM_010200.3NP_034330.2  fibroblast growth factor 13 isoform 1

    See identical proteins and their annotated locations for NP_034330.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    BC018238, CD776909
    Consensus CDS
    CCDS30157.1
    UniProtKB/Swiss-Prot
    P70377
    Related
    ENSMUSP00000033473.5, ENSMUST00000033473.11
    Conserved Domains (1) summary
    smart00442
    Location:67197
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p6 C57BL/6J

    Range
    59062139..59585572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527797.3XP_006527860.1  fibroblast growth factor 13 isoform X2

    See identical proteins and their annotated locations for XP_006527860.1

    Related
    ENSMUSP00000113639.1, ENSMUST00000119833.7
    Conserved Domains (1) summary
    smart00442
    Location:21151
    FGF; Acidic and basic fibroblast growth factor family
  2. XM_006527793.3XP_006527856.1  fibroblast growth factor 13 isoform X1

    See identical proteins and their annotated locations for XP_006527856.1

    Conserved Domains (1) summary
    smart00442
    Location:77207
    FGF; Acidic and basic fibroblast growth factor family
  3. XM_006527796.4XP_006527859.1  fibroblast growth factor 13 isoform X1

    See identical proteins and their annotated locations for XP_006527859.1

    Conserved Domains (1) summary
    smart00442
    Location:77207
    FGF; Acidic and basic fibroblast growth factor family
  4. XM_006527795.1XP_006527858.1  fibroblast growth factor 13 isoform X1

    See identical proteins and their annotated locations for XP_006527858.1

    Conserved Domains (1) summary
    smart00442
    Location:77207
    FGF; Acidic and basic fibroblast growth factor family
  5. XM_006527799.3XP_006527862.1  fibroblast growth factor 13 isoform X3

    Conserved Domains (1) summary
    smart00442
    Location:11141
    FGF; Acidic and basic fibroblast growth factor family
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