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FGF11 fibroblast growth factor 11 [ Homo sapiens (human) ]

Gene ID: 2256, updated on 18-Aug-2020

Summary

Official Symbol
FGF11provided by HGNC
Official Full Name
fibroblast growth factor 11provided by HGNC
Primary source
HGNC:HGNC:3667
See related
Ensembl:ENSG00000161958 MIM:601514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FHF3; FHF-3; FGF-11
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Broad expression in adrenal (RPKM 9.9), skin (RPKM 7.0) and 14 other tissues See more
Orthologs

Genomic context

See FGF11 in Genome Data Viewer
Location:
17p13.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7438298..7444937)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7341784..7348256)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SPEM family member 3 Neighboring gene transmembrane protein 102 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene solute carrier family 35 member G6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SPEM1

Homology

Clone Names

  • FLJ16061, MGC45269, MGC102953

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
regulation of voltage-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 11
Names
fibroblast growth factor homologous factor 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303460.2NP_001290389.1  fibroblast growth factor 11 isoform 2

    See identical proteins and their annotated locations for NP_001290389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC113189
    UniProtKB/Swiss-Prot
    Q92914
    UniProtKB/TrEMBL
    B7Z1C3
    Conserved Domains (1) summary
    smart00442
    Location:10140
    FGF; Acidic and basic fibroblast growth factor family
  2. NM_004112.4NP_004103.1  fibroblast growth factor 11 isoform 1

    See identical proteins and their annotated locations for NP_004103.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC113189
    Consensus CDS
    CCDS11105.1
    UniProtKB/Swiss-Prot
    Q92914
    Related
    ENSP00000293829.4, ENST00000293829.9
    Conserved Domains (1) summary
    smart00442
    Location:69199
    FGF; Acidic and basic fibroblast growth factor family

RNA

  1. NR_130156.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC113189
    Related
    ENST00000575082.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7438298..7444937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p13 PATCHES

    Range
    58755..65394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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