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Wnt2b wingless-type MMTV integration site family, member 2B [ Mus musculus (house mouse) ]

Gene ID: 22414, updated on 9-May-2024

Summary

Official Symbol
Wnt2bprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 2Bprovided by MGI
Primary source
MGI:MGI:1261834
See related
Ensembl:ENSMUSG00000027840 AllianceGenome:MGI:1261834
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt13
Summary
Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including forebrain regionalization; mesenchymal-epithelial cell signaling; and regulation of morphogenesis of a branching structure. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; sensory organ; and urethra. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human WNT2B (Wnt family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 10.5), adrenal adult (RPKM 7.2) and 23 other tissues See more
Orthologs
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Genomic context

See Wnt2b in Genome Data Viewer
Location:
3 F2.2; 3 45.88 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104852121..104869025, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104944805..104961709, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104667925-104668034 Neighboring gene suppression of tumorigenicity 7-like Neighboring gene ribosomal protein S27 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08625 Neighboring gene predicted gene, 46819 Neighboring gene uncharacterized LOC118568635 Neighboring gene CTTNBP2 N-terminal like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in forebrain regionalization IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung induction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mesenchymal-epithelial cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein Wnt-2b
Names
wingless related MMTV integration site 2b
wnt-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009520.3NP_033546.2  protein Wnt-2b

    See identical proteins and their annotated locations for NP_033546.2

    Status: PROVISIONAL

    Source sequence(s)
    AC166156
    Consensus CDS
    CCDS17706.1
    UniProtKB/Swiss-Prot
    O70283, O88530, Q544L3
    Related
    ENSMUSP00000029429.5, ENSMUST00000029429.6
    Conserved Domains (1) summary
    pfam00110
    Location:72378
    wnt; wnt family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    104852121..104869025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)