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WNT2B Wnt family member 2B [ Homo sapiens (human) ]

Gene ID: 7482, updated on 1-Aug-2020

Summary

Official Symbol
WNT2Bprovided by HGNC
Official Full Name
Wnt family member 2Bprovided by HGNC
Primary source
HGNC:HGNC:12781
See related
Ensembl:ENSG00000134245 MIM:601968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WNT13
Summary
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression
Broad expression in ovary (RPKM 4.3), skin (RPKM 3.1) and 21 other tissues See more
Orthologs

Genomic context

See WNT2B in Genome Data Viewer
Location:
1p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (112466541..112530165)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113010040..113063910)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CTTNBP2 N-terminal like Neighboring gene microRNA 4256 Neighboring gene suppression of tumorigenicity 7 like Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
chondrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
cornea development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
forebrain regionalization IEP
Inferred from Expression Pattern
more info
PubMed 
hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
iris morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lens development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lung induction IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEP
Inferred from Expression Pattern
more info
PubMed 
mesenchymal-epithelial cell signaling IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein Wnt-2b
Names
XWNT2, Xenopus, homolog of
wingless-type MMTV integration site family, member 13
wingless-type MMTV integration site family, member 2B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052953.1 RefSeqGene

    Range
    5001..59748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001291880.1NP_001278809.1  protein Wnt-2b isoform 3

    See identical proteins and their annotated locations for NP_001278809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon, compared to variant WNT-2B2. The encoded isoform (3) has a shorter N-terminus, compared to isoform WNT-2B2.
    Source sequence(s)
    AK127449, BC141825
    Consensus CDS
    CCDS76188.1
    UniProtKB/Swiss-Prot
    Q93097
    UniProtKB/TrEMBL
    Q5TEH8
    Related
    ENSP00000256640.5, ENST00000256640.9
    Conserved Domains (1) summary
    pfam00110
    Location:1288
    wnt; wnt family
  2. NM_004185.4NP_004176.2  protein Wnt-2b isoform WNT-2B1

    See identical proteins and their annotated locations for NP_004176.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (WNT-2B1) differs in the 5' UTR and 5' coding region, compared to variant WNT-2B2. The encoded isoform (WNT-2B1) has a shorter and distinct N-terminus, compared to isoform WNT-2B2.
    Source sequence(s)
    AB045116, AK127449, BC141825
    Consensus CDS
    CCDS846.1
    UniProtKB/Swiss-Prot
    Q93097
    Related
    ENSP00000358700.4, ENST00000369686.9
    Conserved Domains (1) summary
    pfam00110
    Location:55361
    wnt; wnt family
  3. NM_024494.3NP_078613.1  protein Wnt-2b isoform WNT-2B2

    See identical proteins and their annotated locations for NP_078613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (WNT-2B2) represents the shortest transcript and encodes the longest isoform (WNT-2B2).
    Source sequence(s)
    AL109932, BC141825
    Consensus CDS
    CCDS847.1
    UniProtKB/Swiss-Prot
    Q93097
    Related
    ENSP00000358698.4, ENST00000369684.5
    Conserved Domains (1) summary
    pfam00110
    Location:74380
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    112466541..112530165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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