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Wnt2 wingless-type MMTV integration site family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 22413, updated on 8-Feb-2024

Summary

Official Symbol
Wnt2provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 2provided by MGI
Primary source
MGI:MGI:98954
See related
Ensembl:ENSMUSG00000010797 AllianceGenome:MGI:98954
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irp; Mirp; Wnt-2; Wnt2a; Int1l1; 2610510E18Rik
Summary
Predicted to enable cytokine activity and frizzled binding activity. Involved in cell proliferation in midbrain and positive regulation of neurogenesis. Acts upstream of or within several processes, including circulatory system development; lung induction; and positive regulation of cell population proliferation. Predicted to be located in collagen-containing extracellular matrix and cytoplasm. Predicted to be extrinsic component of external side of plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including embryo mesenchyme; face; heart and pericardium; reproductive system; and urethra. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 7.8), lung adult (RPKM 3.1) and 6 other tissues See more
Orthologs
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Genomic context

See Wnt2 in Genome Data Viewer
Location:
6 A2; 6 8.08 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (17988939..18032771, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (17985474..18032772, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:17682030-17682331 Neighboring gene metal response element binding transcription factor 2 pseudogene Neighboring gene suppression of tumorigenicity 7 Neighboring gene STARR-seq mESC enhancer starr_15259 Neighboring gene STARR-positive B cell enhancer mm9_chr6:17726341-17726642 Neighboring gene predicted gene, 52895 Neighboring gene STARR-seq mESC enhancer starr_15260 Neighboring gene STARR-seq mESC enhancer starr_15261 Neighboring gene STARR-seq mESC enhancer starr_15263 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within atrial cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell proliferation in midbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell proliferation in midbrain ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell proliferation involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung induction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in midbrain dopaminergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein Wnt-2
Names
INT-1-related protein
wingless-related MMTV integration site 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023653.5NP_076142.3  protein Wnt-2 precursor

    See identical proteins and their annotated locations for NP_076142.3

    Status: VALIDATED

    Source sequence(s)
    AC068561, AK012093, AK045120
    Consensus CDS
    CCDS19928.1
    UniProtKB/Swiss-Prot
    P21552, Q9CZW3
    UniProtKB/TrEMBL
    Q3TJ02, Q8BRC7
    Related
    ENSMUSP00000010941.3, ENSMUST00000010941.6
    Conserved Domains (1) summary
    pfam00110
    Location:43349
    wnt; wnt family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    17988939..18032771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505045.4XP_006505108.1  protein Wnt-2 isoform X1

    UniProtKB/TrEMBL
    Q3TJ02, Q8BRC7
    Conserved Domains (1) summary
    cd19345
    Location:44357
    Wnt_Wnt2; Wnt domain found in protein Wnt-2 and similar proteins