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WNT2 Wnt family member 2 [ Homo sapiens (human) ]

Gene ID: 7472, updated on 24-Nov-2020

Summary

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Official Symbol
WNT2provided by HGNC
Official Full Name
Wnt family member 2provided by HGNC
Primary source
HGNC:HGNC:12780
See related
Ensembl:ENSG00000105989 MIM:147870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRP; INT1L1
Summary
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 44.0), endometrium (RPKM 14.0) and 3 other tissues See more
Orthologs
mouse all

Genomic context

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See WNT2 in Genome Data Viewer
Location:
7q31.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (117275451..117323058, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116916685..116963343, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2 pseudogene Neighboring gene MT-ND2 pseudogene 37 Neighboring gene MT-ND4 pseudogene 6 Neighboring gene greater CFTR locus negative regulatory elements CR12 and CR13 Neighboring gene uncharacterized LOC105375467 Neighboring gene greater CFTR locus negative regulatory element CR15 Neighboring gene greater CFTR locus negative regulatory element CR17 Neighboring gene greater CFTR locus negative regulatory element CR18 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Promoter Methylation Status of WNT2 in Placenta from Patients with Preeclampsia. Liu Y, et al. Med Sci Monit, 2017 Nov 7. PMID 29109390, Free PMC Article
  2. Decreased expression of WNT2 in villi of unexplained recurrent spontaneous abortion patients may cause trophoblast cell dysfunction via downregulated Wnt/β-catenin signaling pathway. Li N, et al. Cell Biol Int, 2017 Aug. PMID 28627774
  3. Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression. Kramer N, et al. Oncogene, 2017 Sep 28. PMID 28553956
  4. WNT2 Promotes Cervical Carcinoma Metastasis and Induction of Epithelial-Mesenchymal Transition. Zhou Y, et al. PLoS One, 2016. PMID 27513465, Free PMC Article
  5. Wnt2 complements Wnt/β-catenin signaling in colorectal cancer. Jung YS, et al. Oncotarget, 2015 Nov 10. PMID 26484565, Free PMC Article

See all (89) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpressed LINC00968 contributes to reduced drug resistance in breast cancer cells by inhibiting the activation of the Wnt2/beta-catenin signaling pathway through silencing WNT2.
    Title: Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2.
  2. The increased expression of DKK1 and decreased expression of WNT2 may be involved in the pathogenesis of early-onset preeclampsia
    Title: Altered DNA methylation and transcription of WNT2 and DKK1 genes in placentas associated with early-onset preeclampsia.
  3. Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway through inhibition of Wnt2 and Fzd2.
    Title: Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway.
  4. The data suggest that Med19 expression correlates with aggressive characteristics of bladder cancer, and Med19 knockdown suppresses the proliferation and migration of cancer cells through down-regulating the Wnt/beta-catenin pathway.
    Title: Knockdown of mediator subunit Med19 suppresses bladder cancer cell proliferation and migration by downregulating Wnt/β-catenin signalling pathway.
  5. The findings of this study have shown that molecular mechanisms, including aberrant activation of the WNT2 gene signaling pathway, may be involved in the pathogenesis of preeclampsia.
    Title: Promoter Methylation Status of WNT2 in Placenta from Patients with Preeclampsia.
  6. SNPs in WNT2 and FOXP2 are associated with clinical symptom severity of autism spectrum disorders.
    Title: The central nervous system patterning gene variants associated with clinical symptom severity of autism spectrum disorders.
  7. WNT2 insufficiency might cause impaired trophoblast cell proliferation and migration via downregulation of Wnt/beta-catenin signaling pathway.
    Title: Decreased expression of WNT2 in villi of unexplained recurrent spontaneous abortion patients may cause trophoblast cell dysfunction via downregulated Wnt/β-catenin signaling pathway.
  8. Three-dimensional organotypic co-culture assays revealed that WNT2-mediated fibroblast motility and extracellular matrix remodeling enhanced cancer cell invasion of cell lines even harboring mutations in the adenomatous polyposis coli/beta-catenin pathway.
    Title: Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression.
  9. Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera.
    Title: Anteroposterior Patterning of Gene Expression in the Human Infant Sclera: Chondrogenic Potential and Wnt Signaling.
  10. data enforced the evidence that knockdown of c-Fos inhibited cell proliferation, migration, and invasion, and promoted the apoptosis of OS cells accompanied by altered expression of Wnt2 and Fzd9
    Title: Involvement of c-Fos in cell proliferation, migration, and invasion in osteosarcoma cells accompanied by altered expression of Wnt2 and Fzd9.
Submit: New GeneRIF Correction See all GeneRIFs (55)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.
GeneReviews: Not available
Wnt signaling and Dupuytren's disease.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with WNT2 promoter to upregulate WNT2 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
receptor ligand activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
  
atrial cardiac muscle tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
  
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
cardiac epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
  
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cell proliferation in midbrain IDA
Inferred from Direct Assay
more info
 PubMed 
cell-cell signaling IDA
Inferred from Direct Assay
more info
 PubMed 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
  
cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
iris morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
  
lens development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
lung development IEA
Inferred from Electronic Annotation
more info
  
lung induction IEA
Inferred from Electronic Annotation
more info
  
mammary gland epithelium development IEP
Inferred from Expression Pattern
more info
 PubMed 
midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
neurogenesis TAS
Traceable Author Statement
more info
 PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of epithelial cell proliferation involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
  
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
  
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
Wnt signalosome IC
Inferred by Curator
more info
 PubMed 
collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
extracellular region TAS
Traceable Author Statement
more info
  
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
extrinsic component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein Wnt-2
Names
Int-1-related protein
epididymis secretory sperm binding protein
int-1-like protein 1
secreted growth factor
wingless-type MMTV integration site family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003391.3 → NP_003382.1  protein Wnt-2 precursor

    See identical proteins and their annotated locations for NP_003382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC006326, BC078170
    Consensus CDS
    CCDS5771.1
    UniProtKB/Swiss-Prot
    P09544
    Related
    ENSP00000265441.3, ENST00000265441.8
    Conserved Domains (1) summary
    pfam00110
    Location:43 → 349
    wnt; wnt family

RNA

  1. NR_024047.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, that significantly impacts the predicted protein, and apparently results in a non-protein coding transcript.
    Source sequence(s)
    AC006326, BC078170
    Related
    ENST00000647844.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    117275451..117323058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09544.1 GenPept UniProtKB/Swiss-Prot:P09544

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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