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Stk24 serine/threonine kinase 24 [ Mus musculus (house mouse) ]

Gene ID: 223255, updated on 8-Feb-2024

Summary

Official Symbol
Stk24provided by MGI
Official Full Name
serine/threonine kinase 24provided by MGI
Primary source
MGI:MGI:2385007
See related
Ensembl:ENSMUSG00000063410 AllianceGenome:MGI:2385007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mst3; MST-3; STE20; 1810013H02Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of axon regeneration; and response to hydrogen peroxide. Predicted to act upstream of or within apoptotic process and phosphorylation. Predicted to be located in Golgi membrane; cytosol; and nucleolus. Is expressed in brain. Orthologous to human STK24 (serine/threonine kinase 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 21.9), large intestine adult (RPKM 15.2) and 28 other tissues See more
Orthologs
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Genomic context

See Stk24 in Genome Data Viewer
Location:
14 E5; 14 64.95 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (121521599..121618269, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (121284187..121380496, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37701 Neighboring gene STARR-seq mESC enhancer starr_37702 Neighboring gene importin 5 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 1 Neighboring gene RIKEN cDNA B930095G15 gene Neighboring gene STARR-seq mESC enhancer starr_37715 Neighboring gene STARR-seq mESC enhancer starr_37718 Neighboring gene STARR-positive B cell enhancer ABC_E1475 Neighboring gene STARR-positive B cell enhancer ABC_E478 Neighboring gene STARR-seq mESC enhancer starr_37728 Neighboring gene STARR-seq mESC enhancer starr_37729 Neighboring gene STARR-positive B cell enhancer ABC_E11584 Neighboring gene predicted gene, 33299 Neighboring gene STARR-seq mESC enhancer starr_37731 Neighboring gene solute carrier family 15 (oligopeptide transporter), member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6330

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase 24
Names
STE20-like kinase MST3
mammalian STE20-like protein kinase 3
mammalian sterile twenty 3 kinase
serine/threonine kinase 24 (STE20 homolog, yeast)
NP_663440.1
XP_006518981.1
XP_011243345.1
XP_017171477.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145465.2NP_663440.1  serine/threonine-protein kinase 24

    See identical proteins and their annotated locations for NP_663440.1

    Status: VALIDATED

    Source sequence(s)
    AK154959, BE687884, BY730101
    Consensus CDS
    CCDS37016.1
    UniProtKB/Swiss-Prot
    Q99KH8
    UniProtKB/TrEMBL
    Q3U335, Q3U3T6
    Related
    ENSMUSP00000078746.8, ENSMUST00000079817.8
    Conserved Domains (2) summary
    smart00220
    Location:24274
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06609
    Location:22295
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    121521599..121618269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518918.3XP_006518981.1  serine/threonine-protein kinase 24 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1197
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011245043.4XP_011243345.1  serine/threonine-protein kinase 24 isoform X2

    UniProtKB/TrEMBL
    Q3U3T6
    Conserved Domains (1) summary
    cd06609
    Location:21294
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
  3. XM_017315988.2XP_017171477.1  serine/threonine-protein kinase 24 isoform X1

    UniProtKB/TrEMBL
    Q3U3T6
    Conserved Domains (1) summary
    cd06609
    Location:34307
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases