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STK24 serine/threonine kinase 24 [ Homo sapiens (human) ]

Gene ID: 8428, updated on 17-Jun-2019

Summary

Official Symbol
STK24provided by HGNC
Official Full Name
serine/threonine kinase 24provided by HGNC
Primary source
HGNC:HGNC:11403
See related
Ensembl:ENSG00000102572 MIM:604984
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST3; STK3; MST3B; STE20; HEL-S-95
Summary
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in esophagus (RPKM 41.4), skin (RPKM 24.6) and 25 other tissues See more
Orthologs

Genomic context

See STK24 in Genome Data Viewer
Location:
13q32.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (98450199..98577151, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99102455..99229396, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 1 Neighboring gene microRNA 3170 Neighboring gene uncharacterized LOC105370327 Neighboring gene STK24 antisense RNA 1 Neighboring gene NUS1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A comprehensive genetic association study of Alzheimer disease in African Americans.
NHGRI GWA Catalog
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.
NHGRI GWA Catalog
Joint influence of small-effect genetic variants on human longevity.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies serine/threonine kinase 24 STK24 is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
    Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
  • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
    Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
execution phase of apoptosis TAS
Traceable Author Statement
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 24
Names
STE20-like kinase 3
STE20-like kinase MST3
epididymis secretory protein Li 95
mammalian STE20-like protein kinase 3
serine/threonine kinase 24 (STE20 homolog, yeast)
sterile 20-like kinase 3
NP_001027467.2
NP_001273578.1
NP_003567.2
XP_005254136.1
XP_016876283.1
XP_024305194.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032296.3NP_001027467.2  serine/threonine-protein kinase 24 isoform b precursor

    See identical proteins and their annotated locations for NP_001027467.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AL137249, BC035578, BC065378, CB996892
    Consensus CDS
    CCDS32001.1
    UniProtKB/Swiss-Prot
    Q9Y6E0
    UniProtKB/TrEMBL
    Q5U0E6, Q6P0Y1
    Related
    ENSP00000442539.2, ENST00000539966.5
    Conserved Domains (1) summary
    cd06609
    Location:22295
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
  2. NM_001286649.1NP_001273578.1  serine/threonine-protein kinase 24 isoform c precursor

    See identical proteins and their annotated locations for NP_001273578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and contains multiple differences in the coding region, compard to variant 1, including initiation of translation at an alternate start codon. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK299140, AL137249, CB996892
    Consensus CDS
    CCDS66573.1
    UniProtKB/TrEMBL
    B4DR80
    Related
    ENSP00000380651.3, ENST00000397517.6
    Conserved Domains (1) summary
    cd06609
    Location:22276
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
  3. NM_003576.4NP_003567.2  serine/threonine-protein kinase 24 isoform a precursor

    See identical proteins and their annotated locations for NP_003567.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also known as MST3b).
    Source sequence(s)
    AF083420, AL137249, DA386652, DA395717
    Consensus CDS
    CCDS9488.1
    UniProtKB/Swiss-Prot
    Q9Y6E0
    Related
    ENSP00000365730.3, ENST00000376547.7
    Conserved Domains (2) summary
    smart00220
    Location:36286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06609
    Location:34307
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    98450199..98577151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020794.2XP_016876283.1  serine/threonine-protein kinase 24 isoform X1

  2. XM_005254079.5XP_005254136.1  serine/threonine-protein kinase 24 isoform X2

    See identical proteins and their annotated locations for XP_005254136.1

    Related
    ENSP00000402764.1, ENST00000444574.1
    Conserved Domains (1) summary
    cl21453
    Location:1197
    PKc_like; Protein Kinases, catalytic domain
  3. XM_024449426.1XP_024305194.1  serine/threonine-protein kinase 24 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1197
    PKc_like; Protein Kinases, catalytic domain
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