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ZSCAN23 zinc finger and SCAN domain containing 23 [ Homo sapiens (human) ]

Gene ID: 222696, updated on 5-Aug-2022

Summary

Official Symbol
ZSCAN23provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 23provided by HGNC
Primary source
HGNC:HGNC:21193
See related
Ensembl:ENSG00000187987 AllianceGenome:HGNC:21193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF390; ZNF453; dJ29K1.3; dJ29K1.3.1
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZSCAN23 in Genome Data Viewer
Location:
6p22.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (28421400..28443491, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (28304101..28314932, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (28400432..28411268, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 968, pseudogene Neighboring gene RNA, U2 small nuclear 45, pseudogene Neighboring gene COX11 pseudogene 1 Neighboring gene olfactory receptor family 2 subfamily E member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99276, MGC126606, MGC126608

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 23
Names
zinc finger protein 390
zinc finger protein 453

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012455.2NP_001012458.1  zinc finger and SCAN domain-containing protein 23

    See identical proteins and their annotated locations for NP_001012458.1

    Status: VALIDATED

    Source sequence(s)
    AL833347, BX283350, Z98745
    Consensus CDS
    CCDS47393.1
    UniProtKB/Swiss-Prot
    Q3MJ62, Q96KV9
    Related
    ENSP00000289788.4, ENST00000289788.5
    Conserved Domains (6) summary
    smart00431
    Location:44156
    SCAN; leucine rich region
    COG5048
    Location:215384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:251271
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:249271
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:45132
    SCAN; SCAN domain
    pfam13465
    Location:264288
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    28421400..28443491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418384.1XP_047274340.1  zinc finger and SCAN domain-containing protein 23 isoform X1

    UniProtKB/Swiss-Prot
    Q96KV9

RNA

  1. XR_007059226.1 RNA Sequence

  2. XR_007059223.1 RNA Sequence

  3. XR_007059224.1 RNA Sequence

  4. XR_007059225.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    28304101..28314932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)