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NAPEPLD N-acyl phosphatidylethanolamine phospholipase D [ Homo sapiens (human) ]

Gene ID: 222236, updated on 5-Sep-2021

Summary

Official Symbol
NAPEPLDprovided by HGNC
Official Full Name
N-acyl phosphatidylethanolamine phospholipase Dprovided by HGNC
Primary source
HGNC:HGNC:21683
See related
Ensembl:ENSG00000161048 MIM:612334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FMP30; C7orf18; NAPE-PLD
Summary
NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]
Expression
Ubiquitous expression in brain (RPKM 8.2), kidney (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

See NAPEPLD in Genome Data Viewer
Location:
7q22.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (103099776..103150001, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102740223..102790448, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 13 Neighboring gene Sharpr-MPRA regulatory region 11249 Neighboring gene armadillo repeat containing 10 Neighboring gene crystallin zeta pseudogene 1 Neighboring gene uncharacterized LOC105375434 Neighboring gene ribosomal protein L19 pseudogene 12 Neighboring gene ribosomal protein L23a pseudogene 95 Neighboring gene DPY19L2 pseudogene 2 Neighboring gene S100A11 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781D1098

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in N-acylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in host-mediated regulation of intestinal microbiota composition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of eating behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to isolation stress IEA
Inferred from Electronic Annotation
more info
 
involved_in retinoid metabolic process TAS
Traceable Author Statement
more info
 
involved_in temperature homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in photoreceptor outer segment membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Names
NAPE-hydrolyzing phospholipase D
NP_001116310.1
NP_001373105.1
NP_001373106.1
NP_001373108.1
NP_001373111.1
NP_001373114.1
NP_001373118.1
NP_001373119.1
NP_001373120.1
NP_001373122.1
NP_001373123.1
NP_001373133.1
NP_001373134.1
NP_001373136.1
NP_001373137.1
NP_001373138.1
NP_001373139.1
NP_001373140.1
NP_001373141.1
NP_001373142.1
NP_945341.3
XP_005250275.1
XP_016867343.1
XP_016867346.1
XP_024302456.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122838.3NP_001116310.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    See identical proteins and their annotated locations for NP_001116310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007683
    Consensus CDS
    CCDS5729.1
    UniProtKB/Swiss-Prot
    Q6IQ20
    Related
    ENSP00000419188.1, ENST00000465647.6
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  2. NM_001386176.1NP_001373105.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  3. NM_001386177.1NP_001373106.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Related
    ENSP00000392775.1, ENST00000427257.5
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  4. NM_001386179.1NP_001373108.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  5. NM_001386182.1NP_001373111.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  6. NM_001386185.1NP_001373114.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  7. NM_001386189.1NP_001373118.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129315
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  8. NM_001386190.1NP_001373119.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  9. NM_001386191.1NP_001373120.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  10. NM_001386193.1NP_001373122.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  11. NM_001386194.1NP_001373123.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  12. NM_001386204.1NP_001373133.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  13. NM_001386205.1NP_001373134.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129237
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  14. NM_001386207.1NP_001373136.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129237
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  15. NM_001386208.1NP_001373137.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  16. NM_001386209.1NP_001373138.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  17. NM_001386210.1NP_001373139.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129313
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  18. NM_001386211.1NP_001373140.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129237
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  19. NM_001386212.1NP_001373141.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  20. NM_001386213.1NP_001373142.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC007683
    Related
    ENSP00000407112.1, ENST00000417955.5
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  21. NM_198990.6NP_945341.3  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform 1

    See identical proteins and their annotated locations for NP_945341.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007683
    Consensus CDS
    CCDS5729.1
    UniProtKB/Swiss-Prot
    Q6IQ20
    Related
    ENSP00000340093.4, ENST00000341533.8
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RNA

  1. NR_169877.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  2. NR_169878.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  3. NR_169879.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  4. NR_169880.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  5. NR_169881.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  6. NR_169882.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  7. NR_170069.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  8. NR_170070.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  9. NR_170071.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  10. NR_170072.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  11. NR_170073.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  12. NR_170074.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  13. NR_170075.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  14. NR_170076.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683
  15. NR_170077.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC007683

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    103099776..103150001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446688.1XP_024302456.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X3

    Conserved Domains (1) summary
    cl23716
    Location:1181
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  2. XM_005250218.3XP_005250275.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2

    See identical proteins and their annotated locations for XP_005250275.1

    UniProtKB/Swiss-Prot
    Q6IQ20
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  3. XM_017011854.2XP_016867343.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X2

    UniProtKB/Swiss-Prot
    Q6IQ20
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  4. XM_017011857.1XP_016867346.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X4

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187559.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    94724..144953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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