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Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018 Apr 10;35(2):215-218. doi: 10.3760/cma.j.issn.1003-9406.2018.02.015.

[Association of polymorphisms of NAPE-PLD and FAAH genes with schizophrenia in Chinese Han population].

[Article in Chinese]

Author information

1
Department of Medical Genetics and Cell Biology of Zhengzhou University Clinical Lab of the Third Affilicated Hospital of Zhengzhou University, Zhengzhou, Henan 450052 China. chengxiaoli@zzu.edu.cn.

Abstract

OBJECTIVE:

To assess the association of polymorphisms of N-acyl-phosphatidylethanolamine-phospholipase D (DAPE-PLD) and fatty acid amide hydrolase (FAAH) genes, as well as their interaction, with schizophrenia.

METHODS:

Polymorphisms of NAPE-PLD rs12540583 and FAAH rs324420, rs2295633, and rs6429600 were determined with PCR - restriction fragment length polymorphism assay and Sanger sequencing. The genotypes of 345 subjects of Han Chinese origin diagnosed with schizophrenia and a 403 controls were compared. The results were analyzed with SPSS 17.0, and the interaction of the two genes was analyzed using a multifactor dimensionality reduction (MDR) method.

RESULTS:

The frequency of NAPE-PLD rs12540583 polymorphism was significantly different between the two groups under both dominant and additive models (χ2=17.18 vs. χ2=18.94, P<0.0125). The frequencies of AC genotype and C allele of the patient group at rs12540583 were higher than those of the controls, and the interaction of NAPE-PLD and FAAH was associated with schizophrenia. A four-loci model (rs12540583, rs324420, rs2295633 and rs6429600) can best model the interaction between NAPE-PLD and FAAH.

CONCLUSION:

The AC genotype and C allele of NAPE-PLD rs12540583 locus are risk factors for schizophrenia, and the interaction between NAPE-PLD rs12540583 and FAAH rs324420, rs2295633 and rs6429600 is associated with schizophrenia.

[Indexed for MEDLINE]

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