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Napepld N-acyl phosphatidylethanolamine phospholipase D [ Mus musculus (house mouse) ]

Gene ID: 242864, updated on 26-Sep-2022

Summary

Official Symbol
Napepldprovided by MGI
Official Full Name
N-acyl phosphatidylethanolamine phospholipase Dprovided by MGI
Primary source
MGI:MGI:2140885
See related
Ensembl:ENSMUSG00000044968 AllianceGenome:MGI:2140885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mbldc1; NAPE-PLD; A530089G06
Summary
Enables N-acylphosphatidylethanolamine-specific phospholipase D activity. Involved in several processes, including N-acylphosphatidylethanolamine metabolic process; host-mediated regulation of intestinal microbiota composition; and positive regulation of brown fat cell differentiation. Acts upstream of or within N-acylethanolamine metabolic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and membrane-bounded organelle. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 7.3), testis adult (RPKM 5.6) and 27 other tissues See more
Orthologs
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Genomic context

See Napepld in Genome Data Viewer
Location:
5; 5 A3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21867899..21906620, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21662901..21701622, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene protein archease pseudogene Neighboring gene armadillo repeat containing 10 Neighboring gene microRNA 12197 Neighboring gene BCL2-associated transcription factor 1 pseudogene Neighboring gene VISTA enhancer mm1463 Neighboring gene predicted gene, 54323 Neighboring gene peptidase (mitochondrial processing) beta Neighboring gene predicted gene 15715

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in N-acylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within N-acylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within N-acylethanolamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in host-mediated regulation of intestinal microbiota composition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of eating behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Names
Metallo-beta-lactamase domain containing 1
NAPE-hydrolyzing phospholipase D
NP_001346892.1
NP_001346893.1
NP_001346894.1
NP_848843.1
XP_006535775.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359963.1NP_001346892.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC125343, AC161484, AK049135
    Consensus CDS
    CCDS19105.1
    UniProtKB/Swiss-Prot
    Q8BH82
    Related
    ENSMUSP00000110872.2, ENSMUST00000115217.8
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  2. NM_001359964.1NP_001346893.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC125343, AC161484
    Conserved Domains (1) summary
    cl23716
    Location:137324
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  3. NM_001359965.1NP_001346894.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC125343, AC161484
    Consensus CDS
    CCDS19105.1
    UniProtKB/Swiss-Prot
    Q8BH82
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
  4. NM_178728.6NP_848843.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b

    See identical proteins and their annotated locations for NP_848843.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC125343, AC161484, BC062890
    Consensus CDS
    CCDS19105.1
    UniProtKB/Swiss-Prot
    Q8BH82
    Related
    ENSMUSP00000054458.9, ENSMUST00000060899.9
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    21867899..21906620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535712.4XP_006535775.1  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1

    See identical proteins and their annotated locations for XP_006535775.1

    UniProtKB/Swiss-Prot
    Q8BH82
    Conserved Domains (1) summary
    cl23716
    Location:129316
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain