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FCGR2A Fc gamma receptor IIa [ Homo sapiens (human) ]

Gene ID: 2212, updated on 22-Sep-2022

Summary

Official Symbol
FCGR2Aprovided by HGNC
Official Full Name
Fc gamma receptor IIaprovided by HGNC
Primary source
HGNC:HGNC:3616
See related
Ensembl:ENSG00000143226 MIM:146790; AllianceGenome:HGNC:3616
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; FcgammaRIIa
Summary
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Expression
Broad expression in appendix (RPKM 39.7), placenta (RPKM 36.5) and 21 other tissues See more
Orthologs
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Genomic context

See FCGR2A in Genome Data Viewer
Location:
1q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161505457..161524048)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160768080..160782453)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161475247..161489619)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371473 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9514 Neighboring gene tRNA-Asp (GTC) 10-1 Neighboring gene tRNA-Gly (anticodon GCC) 2-1 Neighboring gene heat shock protein family A (Hsp70) member 6 Neighboring gene tRNA-Leu (anticodon CAG) 1-6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Cystic fibrosis Compare labs
Malaria, susceptibility to
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
Compare labs
Systemic lupus erythematosus
MedGen: C0024141 OMIM: 152700 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
EBI GWAS Catalog
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
EBI GWAS Catalog
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
EBI GWAS Catalog
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Identification of genetic loci associated with Helicobacter pylori serologic status.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC23887, MGC30032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
low affinity immunoglobulin gamma Fc region receptor II-a
Names
Fc fragment of IgG receptor IIa
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Fc gamma receptor RIIa3
Immunoglobulin G Fc receptor II
fc-gamma-RIIa
fcRII-a
igG Fc receptor II-a

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012066.2 RefSeqGene

    Range
    5043..19415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1109

mRNA and Protein(s)

  1. NM_001136219.3NP_001129691.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor

    See identical proteins and their annotated locations for NP_001129691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA634082, AK315225, AL590385
    Consensus CDS
    CCDS44264.1
    UniProtKB/Swiss-Prot
    P12318, Q8WW64
    Related
    ENSP00000271450.6, ENST00000271450.12
    Conserved Domains (3) summary
    cd05752
    Location:41119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:129205
    IG_like; Immunoglobulin like
  2. NM_001375296.1NP_001362225.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL590385, BC019931, BX379627
    Related
    ENSP00000514258.1, ENST00000699277.1
    Conserved Domains (2) summary
    cd05752
    Location:41119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  3. NM_001375297.1NP_001362226.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL590385
    Conserved Domains (2) summary
    cd05752
    Location:40118
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:122204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  4. NM_021642.5NP_067674.2  low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL590385, BC019931
    Consensus CDS
    CCDS30922.1
    UniProtKB/Swiss-Prot
    P12318
    Related
    ENSP00000356949.4, ENST00000367972.8
    Conserved Domains (3) summary
    cd05752
    Location:40118
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:122204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:128204
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161505457..161524048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000664.2XP_016856153.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

  2. XM_017000665.2XP_016856154.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

  3. XM_017000666.2XP_016856155.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X4

    Conserved Domains (3) summary
    cd05752
    Location:41119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:129205
    IG_like; Immunoglobulin like
  4. XM_047449441.1XP_047305397.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X1

  5. XM_017000663.3XP_016856152.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X2

    Conserved Domains (3) summary
    cd05752
    Location:40118
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:122204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:128204
    IG_like; Immunoglobulin like
  6. XM_011509290.3XP_011507592.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X5

    Conserved Domains (3) summary
    cd05752
    Location:41119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:129205
    IG_like; Immunoglobulin like
  7. XM_011509291.2XP_011507593.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X6

    Conserved Domains (3) summary
    cd05752
    Location:41119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:129205
    IG_like; Immunoglobulin like
  8. XM_024454040.2XP_024309808.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X7

    Conserved Domains (1) summary
    cd05753
    Location:166
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160768080..160782453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)