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FCER1G Fc fragment of IgE receptor Ig [ Homo sapiens (human) ]

Gene ID: 2207, updated on 7-Jun-2020

Summary

Official Symbol
FCER1Gprovided by HGNC
Official Full Name
Fc fragment of IgE receptor Igprovided by HGNC
Primary source
HGNC:HGNC:3611
See related
Ensembl:ENSG00000158869 MIM:147139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRG
Summary
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 140.4), spleen (RPKM 128.5) and 19 other tissues See more
Orthologs

Genomic context

See FCER1G in Genome Data Viewer
Location:
1q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161215295..161219245)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161185087..161189038)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene protoporphyrinogen oxidase Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene apolipoprotein A2 Neighboring gene translocase of outer mitochondrial membrane 40 like Neighboring gene microRNA 5187

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IgE receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IgG binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-epsilon receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell differentiation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
interleukin-3-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
mast cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mast cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neutrophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
phagocytosis, engulfment IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mast cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I hypersensitivity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type III hypersensitivity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type IIa hypersensitivity IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serotonin secretion by platelet IEA
Inferred from Electronic Annotation
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Fc-epsilon receptor I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
high affinity immunoglobulin epsilon receptor subunit gamma
Names
Fc epsilon receptor Ig
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Fc receptor gamma-chain
fc-epsilon RI-gamma
fcRgamma
fceRI gamma
immunoglobulin E receptor, high affinity, gamma chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029043.1 RefSeqGene

    Range
    4999..8949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004106.2NP_004097.1  high affinity immunoglobulin epsilon receptor subunit gamma precursor

    See identical proteins and their annotated locations for NP_004097.1

    Status: REVIEWED

    Source sequence(s)
    AL590714, M33195
    Consensus CDS
    CCDS1225.1
    UniProtKB/Swiss-Prot
    P30273
    Related
    ENSP00000289902.1, ENST00000289902.2
    Conserved Domains (2) summary
    smart00077
    Location:6282
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam11628
    Location:2151
    TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161215295..161219245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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