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Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide [ Mus musculus (house mouse) ]

Gene ID: 14127, updated on 26-Mar-2024

Summary

Official Symbol
Fcer1gprovided by MGI
Official Full Name
Fc receptor, IgE, high affinity I, gamma polypeptideprovided by MGI
Primary source
MGI:MGI:95496
See related
Ensembl:ENSMUSG00000058715 AllianceGenome:MGI:95496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD23; Fce1g; Ly-50; FcR[g]; FcRgamma; FcR-gamma; FcepsilonRI
Summary
Enables IgE receptor activity; IgG binding activity; and identical protein binding activity. Contributes to IgE binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of interleukin-4 production; and serotonin secretion by platelet. Acts upstream of or within several processes, including leukocyte differentiation; positive regulation of cytokine production; and positive regulation of immune response. Located in external side of plasma membrane. Is integral component of plasma membrane. Part of Fc-epsilon receptor I complex. Is expressed in central nervous system; gut; male reproductive gland or organ; and retina. Orthologous to human FCER1G (Fc fragment of IgE receptor Ig). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 104.3), mammary gland adult (RPKM 62.3) and 23 other tissues See more
Orthologs
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Genomic context

See Fcer1g in Genome Data Viewer
Location:
1 H3; 1 79.23 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171057141..171061918, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171229572..171234349, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group I, member 3 Neighboring gene translocase of outer mitochondrial membrane 40-like Neighboring gene STARR-positive B cell enhancer ABC_E1573 Neighboring gene apolipoprotein A-II Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene STARR-seq mESC enhancer starr_03024 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 4 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to IgE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables IgE binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to IgE binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables IgE receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables IgE receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables IgE receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables IgG binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables IgG binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Fc receptor mediated stimulatory signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Fc-epsilon receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Fc-gamma receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Fc-gamma receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell differentiation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within T cell differentiation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-2 production IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in interleukin-3-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mast cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of mast cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mast cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of mast cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mast cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of mast cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type I hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type III hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonin secretion by platelet IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Fc-epsilon receptor I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Fc-epsilon receptor I complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of Fc-gamma receptor III complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
high affinity immunoglobulin epsilon receptor subunit gamma
Names
Fc receptor gamma-chain
fc-epsilon RI-gamma
fceRI gamma
igE Fc receptor subunit gamma

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010185.4NP_034315.1  high affinity immunoglobulin epsilon receptor subunit gamma precursor

    See identical proteins and their annotated locations for NP_034315.1

    Status: VALIDATED

    Source sequence(s)
    BE634435, BY173505, CK791068
    Consensus CDS
    CCDS15483.1
    UniProtKB/Swiss-Prot
    P20491
    Related
    ENSMUSP00000078875.7, ENSMUST00000079957.12
    Conserved Domains (2) summary
    smart00077
    Location:6282
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam11628
    Location:2151
    TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171057141..171061918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)