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Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide [ Mus musculus (house mouse) ]

Gene ID: 14127, updated on 31-Dec-2019

Summary

Official Symbol
Fcer1gprovided by MGI
Official Full Name
Fc receptor, IgE, high affinity I, gamma polypeptideprovided by MGI
Primary source
MGI:MGI:95496
See related
Ensembl:ENSMUSG00000058715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD23; Fce1g; Ly-50; FcR[g]; AI573376; FcRgamma; FcR-gamma; FcepsilonRI
Expression
Broad expression in spleen adult (RPKM 104.3), mammary gland adult (RPKM 62.3) and 23 other tissues See more
Orthologs

Genomic context

See Fcer1g in Genome Data Viewer
Location:
1 H3; 1 79.23 cM
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171229572..171234349, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173159703..173164480, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 1, group I, member 3 Neighboring gene translocase of outer mitochondrial membrane 40-like Neighboring gene apolipoprotein A-II Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
IgE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IgE binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to IgE binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to IgE binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
IgE receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IgE receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
IgE receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
IgG binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IgG binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc receptor mediated stimulatory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc receptor mediated stimulatory signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Fc-epsilon receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Fc-gamma receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-gamma receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
T cell differentiation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell differentiation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
Inferred from Mutant Phenotype
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-2 production IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-3-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mast cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mast cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mast cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mast cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type III hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type IIa hypersensitivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
serotonin secretion by platelet IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Fc-epsilon receptor I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-epsilon receptor I complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
high affinity immunoglobulin epsilon receptor subunit gamma
Names
Fc receptor gamma-chain
fc-epsilon RI-gamma
fceRI gamma
igE Fc receptor subunit gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010185.4NP_034315.1  high affinity immunoglobulin epsilon receptor subunit gamma precursor

    See identical proteins and their annotated locations for NP_034315.1

    Status: VALIDATED

    Source sequence(s)
    BE634435, BY173505, CK791068
    Consensus CDS
    CCDS15483.1
    UniProtKB/Swiss-Prot
    P20491
    Related
    ENSMUSP00000078875.6, ENSMUST00000079957.11
    Conserved Domains (2) summary
    smart00077
    Location:6282
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam11628
    Location:2151
    TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p6 C57BL/6J

    Range
    171229572..171234349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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