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Wapl WAPL cohesin release factor [ Mus musculus (house mouse) ]

Gene ID: 218914, updated on 17-Jan-2023

Summary

Official Symbol
Waplprovided by MGI
Official Full Name
WAPL cohesin release factorprovided by MGI
Primary source
MGI:MGI:2675859
See related
Ensembl:ENSMUSG00000041408 AllianceGenome:MGI:2675859
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FOE; DIF-2; Wapal; A530089A20Rik
Summary
Studies suggest that the protein encoded by this gene is important for the release of cohesin from chromatin. This gene product is thought to be essential for development, and reduced expression of this gene in cells causes defects in chromatin structure. High levels of expression of the human ortholog of this gene are observed in cervical cancers, and expression of the human ortholog of this gene in mice results in tumor formation. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in liver E14 (RPKM 13.4), placenta adult (RPKM 11.9) and 28 other tissues See more
Orthologs
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Genomic context

See Wapl in Genome Data Viewer
Location:
14; 14 B
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34394086..34469940)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34672379..34747983)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene opsin 4 (melanopsin) Neighboring gene predicted gene, 52113 Neighboring gene RIKEN cDNA 5830448L01 gene Neighboring gene RIKEN cDNA A930038B10 gene Neighboring gene predicted gene, 52101 Neighboring gene predicted gene, 30969

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0261

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP-dependent protein-DNA unloader activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chromatin binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cohesin loading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
wings apart-like protein homolog
Names
dioxin-inducible factor 2
friend of EBNA2
wings apart-like homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004436.4NP_001004436.2  wings apart-like protein homolog isoform 1

    See identical proteins and their annotated locations for NP_001004436.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC139434, BG068179, BP757948, BY732412, CJ053978, CJ061782, CJ134128, DV646537, DV659439
    Consensus CDS
    CCDS36880.1
    UniProtKB/Swiss-Prot
    Q65Z40, Q6ZQE9
    Related
    ENSMUSP00000040232.8, ENSMUST00000048263.14
    Conserved Domains (1) summary
    pfam07814
    Location:6471008
    WAPL; Wings apart-like protein regulation of heterochromatin
  2. NM_001301330.1NP_001288259.1  wings apart-like protein homolog isoform 2

    See identical proteins and their annotated locations for NP_001288259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC139434, BG068179, BP757948, BY732412, CF161743, CJ053978, CJ061782, CJ134128, DV646537, DV659439
    Consensus CDS
    CCDS79296.1
    UniProtKB/Swiss-Prot
    Q65Z40
    UniProtKB/TrEMBL
    B7ZP47
    Related
    ENSMUSP00000087481.4, ENSMUST00000090027.11
    Conserved Domains (1) summary
    pfam07814
    Location:6411002
    WAPL; Wings apart-like protein regulation of heterochromatin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    34394086..34469940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518824.5XP_006518887.1  wings apart-like protein homolog isoform X1

    Conserved Domains (1) summary
    pfam07814
    Location:596957
    WAPL; Wings apart-like protein regulation of heterochromatin