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WAPL WAPL cohesin release factor [ Homo sapiens (human) ]

Gene ID: 23063, updated on 6-Nov-2022

Summary

Official Symbol
WAPLprovided by HGNC
Official Full Name
WAPL cohesin release factorprovided by HGNC
Primary source
HGNC:HGNC:23293
See related
Ensembl:ENSG00000062650 MIM:610754; AllianceGenome:HGNC:23293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOE; WAPAL; KIAA0261
Summary
Involved in several processes, including negative regulation of DNA replication; negative regulation of chromatin binding activity; and regulation of sister chromatid cohesion. Located in several cellular components, including Golgi apparatus; intercellular bridge; and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 17.0), lymph node (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

See WAPL in Genome Data Viewer
Location:
10q23.2
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (86435256..86521792, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (87315788..87405903, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88195013..88281549, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13981 Neighboring gene uncharacterized LOC124902473 Neighboring gene Sharpr-MPRA regulatory region 10398 Neighboring gene RNA, U6 small nuclear 780, pseudogene Neighboring gene uncharacterized LOC105378408 Neighboring gene uncharacterized LOC105378407 Neighboring gene uncharacterized LOC105378406

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Genome-wide association study of periodontal pathogen colonization.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cohesin loading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cohesin loading IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome TAS
Traceable Author Statement
more info
 
located_in chromosome, centromeric region TAS
Traceable Author Statement
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
wings apart-like protein homolog
Names
friend of EBNA2 (Epstein-Barr virus nuclear protein 2)
friend of EBNA2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318328.2NP_001305257.1  wings apart-like protein homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL731569, AL844892
    UniProtKB/Swiss-Prot
    Q7Z5K2
    UniProtKB/TrEMBL
    A8K273, B2RTX8
    Conserved Domains (1) summary
    pfam07814
    Location:632992
    WAPL; Wings apart-like protein regulation of heterochromatin
  2. NM_015045.5NP_055860.1  wings apart-like protein homolog isoform 1

    See identical proteins and their annotated locations for NP_055860.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL731569, AL844892
    Consensus CDS
    CCDS7375.1
    UniProtKB/Swiss-Prot
    Q7Z5K2, Q92549
    UniProtKB/TrEMBL
    A8K273, B2RTX8
    Related
    ENSP00000298767.4, ENST00000298767.10
    Conserved Domains (1) summary
    pfam07814
    Location:638998
    WAPL; Wings apart-like protein regulation of heterochromatin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    86435256..86521792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    87315788..87405903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)