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Klf10 Kruppel-like factor 10 [ Mus musculus (house mouse) ]

Gene ID: 21847, updated on 5-Jan-2022

Summary

Official Symbol
Klf10provided by MGI
Official Full Name
Kruppel-like factor 10provided by MGI
Primary source
MGI:MGI:1101353
See related
Ensembl:ENSMUSG00000037465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tieg; mGIF; Egral; Tieg1; EGR[a]; Gdnfif; TIEG-1; AI115143
Summary
Enables core promoter sequence-specific DNA binding activity. Involved in cellular response to starvation and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including bone mineralization; positive regulation of osteoclast differentiation; and somatic stem cell population maintenance. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; humerus; and trunk unsegmented mesenchyme. Orthologous to human KLF10 (Kruppel like factor 10). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in bladder adult (RPKM 10.6), mammary gland adult (RPKM 9.9) and 28 other tissues See more
Orthologs
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Genomic context

See Klf10 in Genome Data Viewer
Location:
15; 15 B3.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (38291708..38300955, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (38291464..38300711, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (38224168..38230462, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SET pseudogene Neighboring gene predicted gene, 53876 Neighboring gene predicted gene, 35248 Neighboring gene predicted gene, 41306 Neighboring gene predicted gene, 41307

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Krueppel-like factor 10
Names
GDNF-inducible factor
TGFB inducible early growth response 1
TGFB-inducible early growth response protein 1
transcription factor GIF
transforming growth factor-beta-inducible early growth response protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289471.1NP_001276400.1  Krueppel-like factor 10 isoform 2

    See identical proteins and their annotated locations for NP_001276400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC122459, AK043433
    Consensus CDS
    CCDS88752.1
    UniProtKB/TrEMBL
    Q8C900
    Related
    ENSMUSP00000154265.2, ENSMUST00000227920.2
    Conserved Domains (4) summary
    COG5048
    Location:373423
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373392
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:368392
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:384411
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001357677.1NP_001344606.1  Krueppel-like factor 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC122459
    Conserved Domains (4) summary
    sd00017
    Location:366385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:421443
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:407430
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:69351
    Atrophin-1; Atrophin-1 family
  3. NM_013692.3NP_038720.1  Krueppel-like factor 10 isoform 1

    See identical proteins and their annotated locations for NP_038720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC122459, AK079679, BY548635
    Consensus CDS
    CCDS27438.1
    UniProtKB/Swiss-Prot
    O89091
    Related
    ENSMUSP00000073690.6, ENSMUST00000074043.7
    Conserved Domains (3) summary
    sd00017
    Location:373392
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:428450
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:414437
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    38291708..38300955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159317.1XP_036015210.1  Krueppel-like factor 10 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:441491
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:441460
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:496518
    zf-C2H2; Zinc finger, C2H2 type
    cd21572
    Location:101436
    KLF10_N; N-terminal domain of Kruppel-like factor 10
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