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Tiam1 T cell lymphoma invasion and metastasis 1 [ Mus musculus (house mouse) ]

Gene ID: 21844, updated on 21-Apr-2024

Summary

Official Symbol
Tiam1provided by MGI
Official Full Name
T cell lymphoma invasion and metastasis 1provided by MGI
Primary source
MGI:MGI:103306
See related
Ensembl:ENSMUSG00000002489 AllianceGenome:MGI:103306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D16Ium10; D16Ium10e
Summary
Enables several functions, including guanyl-nucleotide exchange factor activity; microtubule binding activity; and signaling receptor binding activity. Involved in several processes, including activation of GTPase activity; brain-derived neurotrophic factor receptor signaling pathway; and regulation of dopaminergic neuron differentiation. Acts upstream of or within ephrin receptor signaling pathway; positive regulation of axonogenesis; and small GTPase mediated signal transduction. Located in kinocilium; pericentriolar material; and plasma membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; gonad; sensory organ; and skin. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 9.6), frontal lobe adult (RPKM 5.9) and 22 other tissues See more
Orthologs
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Genomic context

Location:
16 C3.3; 16 51.5 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (89583999..89942488, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (89787111..90145600, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41423 Neighboring gene cyclin G1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41424 Neighboring gene predicted gene, 35500 Neighboring gene STARR-seq mESC enhancer starr_41425 Neighboring gene STARR-seq mESC enhancer starr_41426 Neighboring gene predicted gene, 52239 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:89987347-89987530 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:89994282-89994548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:90042691-90042874 Neighboring gene STARR-seq mESC enhancer starr_41431 Neighboring gene STARR-seq mESC enhancer starr_41432 Neighboring gene predicted gene 2805 Neighboring gene STARR-positive B cell enhancer ABC_E4186 Neighboring gene STARR-seq mESC enhancer starr_41437 Neighboring gene STARR-seq mESC enhancer starr_41438 Neighboring gene predicted gene 10789 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene predicted gene, 35714

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in NMDA selective glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in brain-derived neurotrophic factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Schwann cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axonogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of non-canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in kinocilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in main axon ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor TIAM1
Names
T-lymphoma invasion and metastasis-inducing protein 1
TIAM-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145886.1NP_001139358.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    See identical proteins and their annotated locations for NP_001139358.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK017465, AK136856, AK147392, BC065126, CJ262109, CO042855
    Consensus CDS
    CCDS28314.1
    UniProtKB/Swiss-Prot
    Q60610
    UniProtKB/TrEMBL
    G3UWG2
    Related
    ENSMUSP00000132137.2, ENSMUST00000163370.8
    Conserved Domains (6) summary
    smart00455
    Location:766832
    RBD; Raf-like Ras-binding domain
    smart00325
    Location:10441233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12351406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:572669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
  2. NM_001145887.1NP_001139359.1  rho guanine nucleotide exchange factor TIAM1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks many 5' coding exons, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK136856, AK147392, BC065126, CJ262109, CO042855
    Consensus CDS
    CCDS49904.1
    UniProtKB/TrEMBL
    E9Q1R7, Q3UVX2
    Related
    ENSMUSP00000126020.3, ENSMUST00000164263.9
    Conserved Domains (3) summary
    smart00325
    Location:75264
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:266437
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam00169
    Location:314426
    PH; PH domain
  3. NM_001426931.1NP_001413860.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087840, AC102908, AC122218
    UniProtKB/TrEMBL
    G3UWG2
  4. NM_001426932.1NP_001413861.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087840, AC102908, AC122218, AC132099
    UniProtKB/TrEMBL
    G3UWG2
  5. NM_001426933.1NP_001413862.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087840, AC102908, AC122218, AC132099
    UniProtKB/TrEMBL
    G3UWG2
  6. NM_009384.4NP_033410.2  rho guanine nucleotide exchange factor TIAM1 isoform 1

    See identical proteins and their annotated locations for NP_033410.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC087840, AC102908, AC122218
    Consensus CDS
    CCDS28314.1
    UniProtKB/Swiss-Prot
    Q60610
    UniProtKB/TrEMBL
    G3UWG2
    Related
    ENSMUSP00000002588.4, ENSMUST00000002588.11
    Conserved Domains (6) summary
    smart00455
    Location:766832
    RBD; Raf-like Ras-binding domain
    smart00325
    Location:10441233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12351406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:572669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    89583999..89942488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316936.2XP_017172425.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

    UniProtKB/Swiss-Prot
    Q60610
    UniProtKB/TrEMBL
    G3UWG2
    Conserved Domains (6) summary
    smart00455
    Location:766832
    RBD; Raf-like Ras-binding domain
    smart00325
    Location:10441233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12351406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:572669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
  2. XM_030249040.2XP_030104900.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

    UniProtKB/Swiss-Prot
    Q60610
    UniProtKB/TrEMBL
    G3UWG2
    Conserved Domains (6) summary
    smart00455
    Location:766832
    RBD; Raf-like Ras-binding domain
    smart00325
    Location:10441233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12351406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:572669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
  3. XM_030249041.2XP_030104901.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

    UniProtKB/Swiss-Prot
    Q60610
    UniProtKB/TrEMBL
    G3UWG2
    Conserved Domains (6) summary
    smart00455
    Location:766832
    RBD; Raf-like Ras-binding domain
    smart00325
    Location:10441233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12351406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:572669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
  4. XM_036159872.1XP_036015765.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

    UniProtKB/Swiss-Prot
    Q60610
    UniProtKB/TrEMBL
    G3UWG2
    Conserved Domains (6) summary
    smart00455
    Location:766832
    RBD; Raf-like Ras-binding domain
    smart00325
    Location:10441233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12351406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:572669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
  5. XM_006522982.5XP_006523045.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

    See identical proteins and their annotated locations for XP_006523045.1

    UniProtKB/Swiss-Prot
    Q60610
    UniProtKB/TrEMBL
    G3UWG2
    Conserved Domains (6) summary
    smart00455
    Location:766832
    RBD; Raf-like Ras-binding domain
    smart00325
    Location:10441233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12351406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:572669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
  6. XM_006522983.5XP_006523046.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    Q3UHH6
    Conserved Domains (6) summary
    smart00325
    Location:751940
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:553632
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:139265
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:9421113
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:473542
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:279376
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain