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TIAM1 TIAM Rac1 associated GEF 1 [ Homo sapiens (human) ]

Gene ID: 7074, updated on 9-Oct-2021

Summary

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Official Symbol
TIAM1provided by HGNC
Official Full Name
TIAM Rac1 associated GEF 1provided by HGNC
Primary source
HGNC:HGNC:11805
See related
Ensembl:ENSG00000156299 MIM:600687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIAM-1
Summary
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Expression
Broad expression in esophagus (RPKM 7.7), skin (RPKM 6.8) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See TIAM1 in Genome Data Viewer
Location:
21q22.11
Exon count:
37
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (31118418..31559977, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (32490736..32931400, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene keratin associated protein 19-8 Neighboring gene ubiquitin protein ligase E3A pseudogene 2 Neighboring gene uncharacterized LOC107985487 Neighboring gene uncharacterized LOC105372777 Neighboring gene mitochondrial transcription rescue factor 1 pseudogene Neighboring gene TIAM1 antisense RNA 1 Neighboring gene uncharacterized LOC107985488 Neighboring gene F-box and WD repeat domain containing 11 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tiam1 high expression is associated with poor prognosis in solid cancers: A meta-analysis. Ding J, et al. Medicine (Baltimore), 2019 Nov. PMID 31702612, Free PMC Article
  2. TIAM1 promotes chemoresistance and tumor invasiveness in colorectal cancer. Izumi D, et al. Cell Death Dis, 2019 Mar 19. PMID 30890693, Free PMC Article
  3. Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Poudel KR, et al. Dev Cell, 2018 Jun 18. PMID 29920278, Free PMC Article
  4. Upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome. Yang Y, et al. Hum Pathol, 2018 May. PMID 29452216
  5. The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain. Xu Z, et al. J Biol Chem, 2017 Oct 27. PMID 28882897, Free PMC Article

See all (169) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis.
    Title: Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis.
  2. TIAM1 is overexpressed in colorectal cancer (CRC) tumors from patients who did not respond to chemotherapeutic drugs and levels of TIAM1 expression served as an independent prognostic factor. Cancer associated fibroblasts enhanced CRC chemoresistance through TIAM1 overexpression. These results suggest that TIAM1 regulates chemosensitivity in tumors and stroma and thus may be an attractive therapeutic target.
    Title: TIAM1 promotes chemoresistance and tumor invasiveness in colorectal cancer.
  3. Results suggest that miR-142-5p and T-cell lymphoma invasion and metastasis 1 (Tiam1) may be potential diagnostic markers for colon cancer.
    Title: Diagnostic Value of miR-142-5p and Tiam-1 in Colon Cancer Patients.
  4. The meta-analysis confirmed that Tiam1 higher expression positively correlated with OS and DFS, suggesting that Tiam1 may act as a valuable prognostic predictor.
    Title: Tiam1 high expression is associated with poor prognosis in solid cancers: A meta-analysis.
  5. our study demonstrated that upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome
    Title: Upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome.
  6. Overexpression of miR-10b in HeLa and SiHa suppressed cell proliferation, migration and invasion, and induced apoptosis and miR-10b downregulation had opposite effects. Mechanistically, T-cell lymphoma invasion and metastasis 1 (Tiam1) was identified as a direct and functional target of miR-10b.
    Title: miR-10b Downregulated by DNA Methylation Acts as a Tumor Suppressor in HPV-Positive Cervical Cancer via Targeting Tiam1.
  7. Study in hepatocellular carcinoma (HCC) cells proves that SETDB1 promotes the proliferation and migration of cells by forming SETDB1-Tiam1 compounds. SETDB1-Tiam1 compounds were involved in a novel pathway, which regulated epigenetic modification of gene expression in HCC patients samples.
    Title: Histone methyltransferase SETDB1 promotes cells proliferation and migration by interacting withTiam1 in hepatocellular carcinoma.
  8. Down-regulating Tiam1 expression resulted in the down-regulation of circRNA-ACAP2 expression and up-regulation of miR-21-5P expression.
    Title: The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells.
  9. The effects of Tiam1 on metastasis and EMT mediated by the Wnt/beta-catenin pathway were reversed by Rac1 silencing, suggesting that the prometastatic effect of Tiam1 is mediated by the activation of Rac1. These results indicate that Tiam1 may be a prognostic factor and potential therapeutic target for the treatment of thyroid cancers.
    Title: Tiam1 promotes thyroid carcinoma metastasis by modulating EMT via Wnt/β-catenin signaling.
  10. These findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest that it may be a therapeutic target in multiple sclerosis.
    Title: Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.
Submit: New GeneRIF Correction See all GeneRIFs (110)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
GeneReviews: Not available
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
GeneReviews: Not available
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36302

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NMDA selective glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in neuron projection extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Schwann cell chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of epithelial to mesenchymal transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dopaminergic neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of modification of postsynaptic actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of non-canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in response to cocaine IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in axonal growth cone IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extrinsic component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in main axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
Names
T cell lymphoma invasion and metastasis 1
human T-lymphoma invasion and metastasis inducing TIAM1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353684.2 → NP_001340613.1  rho guanine nucleotide exchange factor TIAM1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000246
    Consensus CDS
    CCDS86983.1
    Related
    ENSP00000490786.1, ENST00000636887.1
    Conserved Domains (2) summary
    smart00325
    Location:77 → 266
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:268 → 439
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

  2. NM_001353685.2 → NP_001340614.1  rho guanine nucleotide exchange factor TIAM1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP000246
    Conserved Domains (2) summary
    smart00325
    Location:52 → 241
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:243 → 414
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

  3. NM_001353686.2 → NP_001340615.1  rho guanine nucleotide exchange factor TIAM1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248
    Conserved Domains (5) summary
    cd01818
    Location:766 → 841
    TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor
    smart00325
    Location:1019 → 1208
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1210 → 1381
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

  4. NM_001353687.2 → NP_001340616.1  rho guanine nucleotide exchange factor TIAM1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248
    Conserved Domains (5) summary
    cd01818
    Location:741 → 816
    TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor
    smart00325
    Location:1019 → 1208
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:821 → 900
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1210 → 1381
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

  5. NM_001353688.1 → NP_001340617.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  6. NM_001353689.1 → NP_001340618.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  7. NM_001353690.1 → NP_001340619.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251
    Consensus CDS
    CCDS13609.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  8. NM_001353691.1 → NP_001340620.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  9. NM_001353692.1 → NP_001340621.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  10. NM_001353693.1 → NP_001340622.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  11. NM_001353694.2 → NP_001340623.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248
    Consensus CDS
    CCDS13609.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  12. NM_003253.3 → NP_003244.2  rho guanine nucleotide exchange factor TIAM1 isoform 1

    See identical proteins and their annotated locations for NP_003244.2

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q13009
    Related
    ENSP00000286827.3, ENST00000286827.7
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    31118418..31559977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529712.1 → XP_011528014.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011528014.1

    UniProtKB/Swiss-Prot
    Q13009
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  2. XM_017028448.1 → XP_016883937.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q13009
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  3. XM_024452127.1 → XP_024307895.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  4. XM_005261040.2 → XP_005261097.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam00169
    Location:445 → 547
    PH; PH domain
    cl00155
    Location:766 → 841
    UBQ; Ubiquitin-like proteins

  5. XM_011529713.1 → XP_011528015.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011528015.1

    UniProtKB/Swiss-Prot
    Q13009
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  6. XM_005261038.3 → XP_005261095.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005261095.1

    UniProtKB/Swiss-Prot
    Q13009
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  7. XM_017028450.1 → XP_016883939.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q13009
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  8. XM_017028451.2 → XP_016883940.1  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q13009
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13009.2 GenPept UniProtKB/Swiss-Prot:Q13009

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