U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TIAM1 TIAM Rac1 associated GEF 1 [ Homo sapiens (human) ]

Gene ID: 7074, updated on 17-May-2023

Summary

Go to the top of the page Help
Official Symbol
TIAM1provided by HGNC
Official Full Name
TIAM Rac1 associated GEF 1provided by HGNC
Primary source
HGNC:HGNC:11805
See related
Ensembl:ENSG00000156299 MIM:600687; AllianceGenome:HGNC:11805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDLDS; TIAM-1
Summary
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Expression
Broad expression in esophagus (RPKM 7.7), skin (RPKM 6.8) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TIAM1 in Genome Data Viewer
Location:
21q22.11
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (31118418..31559087, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (29486163..29927068, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (32490736..32931400, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene keratin associated protein 19-8 Neighboring gene ubiquitin protein ligase E3A pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:32530991-32531520 Neighboring gene Sharpr-MPRA regulatory region 15669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:32554821-32555320 Neighboring gene uncharacterized LOC105372777 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:32710674-32711873 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:32738744-32739943 Neighboring gene mitochondrial transcription rescue factor 1 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:32842913-32843876 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:32867589-32868090 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:32868091-32868590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:32894311-32894810 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr21:32917456-32918188 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:32925735-32926454 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:32926455-32927174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:32929546-32930359 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:32931173-32931985 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:32955714-32956498 Neighboring gene TIAM1 antisense RNA 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. T-lymphoma invasion and metastasis 1 promotes invadopodia formation and is regulated by the PI3K/Akt signaling pathway in hepatocellular carcinoma. Wang B, et al. Exp Cell Res, 2021 Oct 15. PMID 34487727
  2. Tiam1 high expression is associated with poor prognosis in solid cancers: A meta-analysis. Ding J, et al. Medicine (Baltimore), 2019 Nov. PMID 31702612, Free PMC Article
  3. TIAM1 promotes chemoresistance and tumor invasiveness in colorectal cancer. Izumi D, et al. Cell Death Dis, 2019 Mar 19. PMID 30890693, Free PMC Article
  4. Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Poudel KR, et al. Dev Cell, 2018 Jun 18. PMID 29920278, Free PMC Article
  5. Upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome. Yang Y, et al. Hum Pathol, 2018 May. PMID 29452216

See all (181) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization.
    Title: miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization.
  2. Fibulin-3 sponges Tiam1 to manipulate MMP-7 activity through beta-catenin signaling in oral squamous cell carcinoma.
    Title: Fibulin-3 sponges Tiam1 to manipulate MMP-7 activity through β-catenin signaling in oral squamous cell carcinoma.
  3. TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change.
    Title: TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change.
  4. Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer.
    Title: Whole Genome Sequencing Prioritizes CHEK2, EWSR1, and TIAM1 as Possible Predisposition Genes for Familial Non-Medullary Thyroid Cancer.
  5. Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.
    Title: Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma.
  6. T-lymphoma invasion and metastasis 1 promotes invadopodia formation and is regulated by the PI3K/Akt signaling pathway in hepatocellular carcinoma.
    Title: T-lymphoma invasion and metastasis 1 promotes invadopodia formation and is regulated by the PI3K/Akt signaling pathway in hepatocellular carcinoma.
  7. Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis.
    Title: Tumor-associated mesenchymal stem cells promote hepatocellular carcinoma metastasis via a DNM3OS/KDM6B/TIAM1 axis.
  8. TIAM1 is overexpressed in colorectal cancer (CRC) tumors from patients who did not respond to chemotherapeutic drugs and levels of TIAM1 expression served as an independent prognostic factor. Cancer associated fibroblasts enhanced CRC chemoresistance through TIAM1 overexpression. These results suggest that TIAM1 regulates chemosensitivity in tumors and stroma and thus may be an attractive therapeutic target.
    Title: TIAM1 promotes chemoresistance and tumor invasiveness in colorectal cancer.
  9. Results suggest that miR-142-5p and T-cell lymphoma invasion and metastasis 1 (Tiam1) may be potential diagnostic markers for colon cancer.
    Title: Diagnostic Value of miR-142-5p and Tiam-1 in Colon Cancer Patients.
  10. The meta-analysis confirmed that Tiam1 higher expression positively correlated with OS and DFS, suggesting that Tiam1 may act as a valuable prognostic predictor.
    Title: Tiam1 high expression is associated with poor prognosis in solid cancers: A meta-analysis.
Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Neurodevelopmental disorder with language delay and seizures
MedGen: C5676998 OMIM: 619908 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ36302

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rac protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of epithelial to mesenchymal transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of dopaminergic neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of non-canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
  
involved_in small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
rho guanine nucleotide exchange factor TIAM1
Names
T cell lymphoma invasion and metastasis 1
T-lymphoma invasion and metastasis-inducing protein 1
human T-lymphoma invasion and metastasis inducing TIAM1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353684.2 → NP_001340613.1  rho guanine nucleotide exchange factor TIAM1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP000246
    Consensus CDS
    CCDS86983.1
    UniProtKB/TrEMBL
    A0A1B0GW57
    Related
    ENSP00000490786.1, ENST00000636887.1
    Conserved Domains (2) summary
    smart00325
    Location:77 → 266
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:268 → 439
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

  2. NM_001353685.2 → NP_001340614.1  rho guanine nucleotide exchange factor TIAM1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP000246
    Conserved Domains (2) summary
    smart00325
    Location:52 → 241
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:243 → 414
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

  3. NM_001353686.2 → NP_001340615.1  rho guanine nucleotide exchange factor TIAM1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248
    Conserved Domains (5) summary
    cd01818
    Location:766 → 841
    TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor
    smart00325
    Location:1019 → 1208
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1210 → 1381
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

  4. NM_001353687.2 → NP_001340616.1  rho guanine nucleotide exchange factor TIAM1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248
    Related
    ENSP00000388217.2, ENST00000455508.2
    Conserved Domains (5) summary
    cd01818
    Location:741 → 816
    TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor
    smart00325
    Location:1019 → 1208
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:821 → 900
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1210 → 1381
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

  5. NM_001353688.1 → NP_001340617.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  6. NM_001353689.1 → NP_001340618.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  7. NM_001353690.1 → NP_001340619.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  8. NM_001353691.1 → NP_001340620.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  9. NM_001353692.1 → NP_001340621.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  10. NM_001353693.1 → NP_001340622.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  11. NM_001353694.2 → NP_001340623.1  rho guanine nucleotide exchange factor TIAM1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27
    Related
    ENSP00000441570.2, ENST00000541036.6
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

  12. NM_003253.3 → NP_003244.2  rho guanine nucleotide exchange factor TIAM1 isoform 1

    See identical proteins and their annotated locations for NP_003244.2

    Status: REVIEWED

    Source sequence(s)
    AP000246, AP000247, AP000248, AP000251, AP000563
    Consensus CDS
    CCDS13609.1
    UniProtKB/Swiss-Prot
    Q13009, Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27
    Related
    ENSP00000286827.3, ENST00000286827.7
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam02196
    Location:766 → 835
    RBD; Raf-like Ras-binding domain
    pfam18385
    Location:572 → 669
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    31118418..31559087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440969.1 → XP_047296925.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

    UniProtKB/Swiss-Prot
    Q17RT7
    UniProtKB/TrEMBL
    A0A2X0TW27

  2. XM_005261040.3 → XP_005261097.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TN84
    Related
    ENSP00000513591.1, ENST00000698169.1
    Conserved Domains (6) summary
    smart00325
    Location:1044 → 1233
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:846 → 925
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:432 → 558
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1235 → 1406
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam00169
    Location:445 → 547
    PH; PH domain
    cl00155
    Location:766 → 841
    UBQ; Ubiquitin-like proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    29486163..29927068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324807.1 → XP_054180782.1  rho guanine nucleotide exchange factor TIAM1 isoform X1

  2. XM_054324808.1 → XP_054180783.1  rho guanine nucleotide exchange factor TIAM1 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TN84
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13009.2 GenPept UniProtKB/Swiss-Prot:Q13009

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous