TIAM1 T cell lymphoma invasion and metastasis 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TIAM1provided by HGNC
Official Full Name: T cell lymphoma invasion and metastasis 1provided by HGNC
Primary source: HGNC:HGNC:11805
See related: Ensembl:ENSG00000156299 MIM:600687
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIAM-1
Summary: This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Expression: Broad expression in esophagus (RPKM 7.7), skin (RPKM 6.8) and 23 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 21q22.11

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	21	NC_000021.9 (31118418..31559977, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (32490736..32931290, complement)

Chromosome 21 - NC_000021.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

our study demonstrated that upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome
Title: Upregulation of Tiam1 contributes to cervical cancer disease progression and indicates poor survival outcome.
Overexpression of miR-10b in HeLa and SiHa suppressed cell proliferation, migration and invasion, and induced apoptosis and miR-10b downregulation had opposite effects. Mechanistically, T-cell lymphoma invasion and metastasis 1 (Tiam1) was identified as a direct and functional target of miR-10b.
Title: miR-10b Downregulated by DNA Methylation Acts as a Tumor Suppressor in HPV-Positive Cervical Cancer via Targeting Tiam1.
Study in hepatocellular carcinoma (HCC) cells proves that SETDB1 promotes the proliferation and migration of cells by forming SETDB1-Tiam1 compounds. SETDB1-Tiam1 compounds were involved in a novel pathway, which regulated epigenetic modification of gene expression in HCC patients samples.
Title: Histone methyltransferase SETDB1 promotes cells proliferation and migration by interacting withTiam1 in hepatocellular carcinoma.
Down-regulating Tiam1 expression resulted in the down-regulation of circRNA-ACAP2 expression and up-regulation of miR-21-5P expression.
Title: The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells.
The effects of Tiam1 on metastasis and EMT mediated by the Wnt/beta-catenin pathway were reversed by Rac1 silencing, suggesting that the prometastatic effect of Tiam1 is mediated by the activation of Rac1. These results indicate that Tiam1 may be a prognostic factor and potential therapeutic target for the treatment of thyroid cancers.
Title: Tiam1 promotes thyroid carcinoma metastasis by modulating EMT via Wnt/β-catenin signaling.
These findings highlight a regulatory pathway of Tiam1/Rac1 in Th17 cells and suggest that it may be a therapeutic target in multiple sclerosis.
Title: Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.
Competing interactions of EndoA3 with membrane versus TIAM1 modulate hyperproliferative and metastatic phenotypes. Disruption of EndoA3-membrane interactions stimulates TIAM1 and small GTPases in vitro, and further promotes pro-metastatic phenotypes in vivo.
Title: Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.
PDZ domains direct protein-protein interactions and serve as models for protein design. This study optimized a protein design energy function for the Tiam1 and Cask PDZ domains that combines a molecular mechanics energy, Generalized Born solvent, and an empirical unfolded state model.
Title: Computational Design of the Tiam1 PDZ Domain and Its Ligand Binding.
Clinical outcome was improved in tumors where a TIAM1 variant was present concomitantly with either ALK mutation or MYCN amplification.
Title: TIAM1 variants improve clinical outcome in neuroblastoma.
the Ser179Glu mutant of SDC-4 binds strongly Tiam1, a Rac1-GEF reducing Rac1-GTP by 3-fold in MCF-7 breast adenocarcinoma cells.
Title: The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
Arf6 downstream pathway, organism-specific biosystem
Arf6 downstream pathway
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
CDC42 signaling events, organism-specific biosystem
CDC42 signaling events
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
Class I PI3K signaling events, organism-specific biosystem
Class I PI3K signaling events
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
E-cadherin signaling in the nascent adherens junction
EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
EPHA2 forward signaling, organism-specific biosystem (from Pathway Interaction Database)
EPHA2 forward signaling, organism-specific biosystem
EPHA2 forward signaling
EPHB-mediated forward signaling, organism-specific biosystem (from REACTOME)
EPHB-mediated forward signaling, organism-specific biosystemMultiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase ...
Ephrin B reverse signaling, organism-specific biosystem (from Pathway Interaction Database)
Ephrin B reverse signaling, organism-specific biosystem
Ephrin B reverse signaling
G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
LPA receptor mediated events, organism-specific biosystem
LPA receptor mediated events
NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
Neurotrophic factor-mediated Trk receptor signaling
PDGF Pathway, organism-specific biosystem (from WikiPathways)
PDGF Pathway, organism-specific biosystemPDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; H...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Rap1 signaling pathway, organism-specific biosystem (from KEGG)
Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
Rap1 signaling pathway, conserved biosystem (from KEGG)
Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
Ras signaling pathway, organism-specific biosystem (from KEGG)
Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
Regulation of RAC1 activity, organism-specific biosystem
Regulation of RAC1 activity
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
Rho GTPase cycle, organism-specific biosystem (from REACTOME)
Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
Tight junction, organism-specific biosystem (from KEGG)
Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
Tight junction, conserved biosystem (from KEGG)
Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
cAMP signaling pathway, organism-specific biosystem (from KEGG)
cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
cAMP signaling pathway, conserved biosystem (from KEGG)
cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-150949 (e-PCR)
- UniSTS:173338

RH123331 (e-PCR)
- UniSTS:135708

SHGC-87547 (e-PCR)
- UniSTS:40239

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-6822 (e-PCR)
- UniSTS:84022

RH123879 (e-PCR)
- UniSTS:136254

TIAM1 (e-PCR)
- UniSTS:506184

TIAM1_7227 (e-PCR)
- UniSTS:466508

D21S1862 (e-PCR)
- UniSTS:22115

NIB1194 (e-PCR)
- UniSTS:21349

RH48581 (e-PCR)
- UniSTS:37225

D21S1681 (e-PCR)
- UniSTS:150391

SHGC-51891 (e-PCR)
- UniSTS:33407

RH122439 (e-PCR)
- UniSTS:135310

D11S3114 (e-PCR)
- UniSTS:152207

SHGC-81220 (e-PCR)
- UniSTS:102038

SHGC-170078 (e-PCR)
- UniSTS:173728

SHGC-30615 (e-PCR)
- UniSTS:56228

D21S1854 (e-PCR)
- UniSTS:8119

SHGC-170314 (e-PCR)
- UniSTS:173770

SHGC-170316 (e-PCR)
- UniSTS:173771

D21S1909 (e-PCR), detects polymorphism
- UniSTS:39372

D21S2049 (e-PCR)
- UniSTS:69840

G34727 (e-PCR)
- UniSTS:6361

D21S1280 (e-PCR)
- UniSTS:148705

HSC1YE072 (e-PCR)
- UniSTS:69861

D21S305 (e-PCR)
- UniSTS:147689

D21S310 (e-PCR)
- UniSTS:147694

RH68783 (e-PCR)
- UniSTS:44798

Homology

Homologs of the TIAM1 gene: The TIAM1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 232 organisms have orthologs with human gene TIAM1
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
Rac guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
Rac guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
Rho guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
guanyl-nucleotide exchange factor activity	EXP Inferred from Experiment more info	PubMed
kinase binding	IPI Inferred from Physical Interaction more info	PubMed
lipid binding	IEA Inferred from Electronic Annotation more info
microtubule binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
NMDA selective glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
Rac protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
Wnt signaling pathway, planar cell polarity pathway	NAS Non-traceable Author Statement more info	PubMed
activation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
ephrin receptor signaling pathway	TAS Traceable Author Statement more info
neuron projection extension	IEA Inferred from Electronic Annotation more info
positive regulation of JUN kinase activity	IEA Inferred from Electronic Annotation more info
positive regulation of Schwann cell chemotaxis	IEA Inferred from Electronic Annotation more info
positive regulation of apoptotic process	TAS Traceable Author Statement more info
positive regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of epithelial to mesenchymal transition	NAS Non-traceable Author Statement more info	PubMed
positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
protein localization to membrane	IEA Inferred from Electronic Annotation more info
regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
regulation of dopaminergic neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
regulation of modification of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
regulation of non-canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
response to cocaine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
axonal growth cone	IEA Inferred from Electronic Annotation more info
cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
dendritic spine	IEA Inferred from Electronic Annotation more info
extrinsic component of cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
extrinsic component of postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
glutamatergic synapse	IEA Inferred from Electronic Annotation more info
main axon	IEA Inferred from Electronic Annotation more info
microtubule	IEA Inferred from Electronic Annotation more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T-lymphoma invasion and metastasis-inducing protein 1

Names: human T-lymphoma invasion and metastasis inducing TIAM1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001353684.1 → NP_001340613.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 2

Status: REVIEWED

Source sequence(s)

AP000246

Consensus CDS

CCDS86983.1

Related

ENSP00000490786.1, ENST00000636887.1

Conserved Domains (2) summary

smart00325
Location:77 → 266

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01255
Location:268 → 439

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353685.1 → NP_001340614.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 3

Status: REVIEWED

Source sequence(s)

AP000246

Conserved Domains (2) summary

smart00325
Location:52 → 241

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01255
Location:243 → 414

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353686.1 → NP_001340615.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 4

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1019 → 1208

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1210 → 1381

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353687.1 → NP_001340616.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 4

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248

Conserved Domains (5) summary

cd01818
Location:741 → 816

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1019 → 1208

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:821 → 900

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1210 → 1381

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353688.1 → NP_001340617.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353689.1 → NP_001340618.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353690.1 → NP_001340619.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251

Consensus CDS

CCDS13609.1

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353691.1 → NP_001340620.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353692.1 → NP_001340621.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353693.1 → NP_001340622.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_001353694.1 → NP_001340623.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform 1

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248

Consensus CDS

CCDS13609.1

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
NM_003253.3 → NP_003244.2 T-lymphoma invasion and metastasis-inducing protein 1 isoform 1

See identical proteins and their annotated locations for NP_003244.2

Status: REVIEWED

Source sequence(s)

AP000246, AP000247, AP000248, AP000251, AP000563

Consensus CDS

CCDS13609.1

UniProtKB/Swiss-Prot

Q13009

Related

ENSP00000286827.3, ENST00000286827.7

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000021.9 Reference GRCh38.p13 Primary Assembly

Range

31118418..31559977 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011529712.1 → XP_011528014.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

See identical proteins and their annotated locations for XP_011528014.1

UniProtKB/Swiss-Prot

Q13009

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
XM_017028448.1 → XP_016883937.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q13009

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
XM_024452127.1 → XP_024307895.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
XM_005261040.2 → XP_005261097.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform X2

Conserved Domains (6) summary

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain

pfam00169
Location:445 → 547

PH; PH domain

cl00155
Location:766 → 841

UBQ; Ubiquitin-like proteins
XM_011529713.1 → XP_011528015.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

See identical proteins and their annotated locations for XP_011528015.1

UniProtKB/Swiss-Prot

Q13009

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
XM_005261038.3 → XP_005261095.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

See identical proteins and their annotated locations for XP_005261095.1

UniProtKB/Swiss-Prot

Q13009

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
XM_017028450.1 → XP_016883939.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q13009

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
XM_017028451.2 → XP_016883940.1 T-lymphoma invasion and metastasis-inducing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q13009

Conserved Domains (5) summary

cd01818
Location:766 → 841

TIAM1_RBD; Ubiquitin domain of Tiam1 guanine nucleotide exchange factor

smart00325
Location:1044 → 1233

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00992
Location:846 → 925

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01230
Location:432 → 558

PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain

cd01255
Location:1235 → 1406

PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain