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Cdc27 cell division cycle 27 [ Mus musculus (house mouse) ]

Gene ID: 217232, updated on 18-Apr-2024

Summary

Official Symbol
Cdc27provided by MGI
Official Full Name
cell division cycle 27provided by MGI
Primary source
MGI:MGI:102685
See related
Ensembl:ENSMUSG00000020687 AllianceGenome:MGI:102685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APC3
Summary
Predicted to enable protein phosphatase binding activity. Predicted to be involved in cell division; cellular protein metabolic process; and regulation of mitotic sister chromatid separation. Predicted to be located in centrosome; mitotic spindle; and nucleoplasm. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Is expressed in head. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.7), placenta adult (RPKM 12.0) and 25 other tissues See more
Orthologs
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Genomic context

Location:
11 E1; 11 67.79 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104393350..104441371, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104502524..104550620, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene predicted gene, 22743 Neighboring gene STARR-seq mESC enhancer starr_30878 Neighboring gene STARR-seq mESC enhancer starr_30880 Neighboring gene STARR-seq mESC enhancer starr_30882 Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:104286345-104286585 Neighboring gene STARR-seq mESC enhancer starr_30888 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104322909-104323210 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104330691-104330991 Neighboring gene STARR-seq mESC enhancer starr_30889 Neighboring gene STARR-seq mESC enhancer starr_30890 Neighboring gene myosin, light polypeptide 4 Neighboring gene predicted gene 11665 Neighboring gene TROVE domain family, member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cell division cycle protein 27 homolog
Names
cell division cycle 27 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285988.2NP_001272917.1  cell division cycle protein 27 homolog isoform 1

    See identical proteins and their annotated locations for NP_001272917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL603709
    UniProtKB/Swiss-Prot
    A2A6Q5
    Conserved Domains (5) summary
    COG0457
    Location:507768
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:573601
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:641673
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13181
    Location:745775
    TPR_8; Tetratricopeptide repeat
  2. NM_001285989.2NP_001272918.1  cell division cycle protein 27 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AL603709
    UniProtKB/TrEMBL
    Q3TTW1
    Conserved Domains (5) summary
    COG0457
    Location:501762
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:567595
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:635667
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13181
    Location:739769
    TPR_8; Tetratricopeptide repeat
  3. NM_001285990.2NP_001272919.1  cell division cycle protein 27 homolog isoform 4

    See identical proteins and their annotated locations for NP_001272919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AL603709
    Conserved Domains (5) summary
    COG0457
    Location:373634
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:439467
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:507539
    TPR_1; Tetratricopeptide repeat
    pfam13181
    Location:611641
    TPR_8; Tetratricopeptide repeat
    pfam13424
    Location:329400
    TPR_12; Tetratricopeptide repeat
  4. NM_145436.3NP_663411.2  cell division cycle protein 27 homolog isoform 2

    See identical proteins and their annotated locations for NP_663411.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL603709
    Consensus CDS
    CCDS36354.1
    UniProtKB/Swiss-Prot
    A2A6Q5, A2A6Q6, B2RXS0
    Related
    ENSMUSP00000091452.3, ENSMUST00000093923.9
    Conserved Domains (5) summary
    COG0457
    Location:502763
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:568596
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:636668
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13181
    Location:740770
    TPR_8; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    104393350..104441371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156600.1XP_036012493.1  cell division cycle protein 27 homolog isoform X4

    Conserved Domains (2) summary
    COG0457
    Location:405666
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:471499
    TPR; TPR repeat [structural motif]
  2. XM_036156599.1XP_036012492.1  cell division cycle protein 27 homolog isoform X3

    Conserved Domains (2) summary
    COG0457
    Location:441702
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:507535
    TPR; TPR repeat [structural motif]
  3. XM_036156597.1XP_036012490.1  cell division cycle protein 27 homolog isoform X2

    Conserved Domains (2) summary
    COG0457
    Location:179440
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245273
    TPR; TPR repeat [structural motif]
  4. XM_036156596.1XP_036012489.1  cell division cycle protein 27 homolog isoform X2

    Conserved Domains (2) summary
    COG0457
    Location:179440
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245273
    TPR; TPR repeat [structural motif]
  5. XM_006533052.5XP_006533115.1  cell division cycle protein 27 homolog isoform X2

    See identical proteins and their annotated locations for XP_006533115.1

    Conserved Domains (2) summary
    COG0457
    Location:179440
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245273
    TPR; TPR repeat [structural motif]
  6. XM_036156598.1XP_036012491.1  cell division cycle protein 27 homolog isoform X2

    Conserved Domains (2) summary
    COG0457
    Location:179440
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:245273
    TPR; TPR repeat [structural motif]
  7. XM_006533050.4XP_006533113.1  cell division cycle protein 27 homolog isoform X1

    UniProtKB/Swiss-Prot
    A2A6Q5
    Related
    ENSMUSP00000102575.3, ENSMUST00000106962.9
    Conserved Domains (3) summary
    COG0457
    Location:508769
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:574602
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
  8. XM_036156601.1XP_036012494.1  cell division cycle protein 27 homolog isoform X5

    Conserved Domains (2) summary
    COG0457
    Location:441701
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:507535
    TPR; TPR repeat [structural motif]