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CDC27 cell division cycle 27 [ Homo sapiens (human) ]

Gene ID: 996, updated on 9-Feb-2020

Summary

Official Symbol
CDC27provided by HGNC
Official Full Name
cell division cycle 27provided by HGNC
Primary source
HGNC:HGNC:1728
See related
Ensembl:ENSG00000004897 MIM:116946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E
Summary
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in thyroid (RPKM 20.3), testis (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See CDC27 in Genome Data Viewer
Location:
17q21.32
Exon count:
20
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (47117703..47189295, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45195310..45266665, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene uncharacterized LOC101927060 Neighboring gene leucine rich repeat containing 37 member A17, pseudogene Neighboring gene reprimo like Neighboring gene RNA, 7SL, cytoplasmic 270, pseudogene Neighboring gene protein GVQW1-like Neighboring gene CRISPRi-validated cis-regulatory element chr17.3215 Neighboring gene ribosomal protein S2 pseudogene 47 Neighboring gene myosin light chain 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell division cycle protein 27 homolog
Names
D0S1430E, D17S978E
anaphase promoting complex subunit 3
anaphase-promoting complex, protein 3
cell division cycle 27 homolog
nuc2 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114091.4NP_001107563.1  cell division cycle protein 27 homolog isoform 1

    See identical proteins and their annotated locations for NP_001107563.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA927469, AC002558, BC011656, HY023336
    Consensus CDS
    CCDS45720.1
    UniProtKB/Swiss-Prot
    P30260
    Related
    ENSP00000434614.1, ENST00000531206.5
    Conserved Domains (5) summary
    COG0457
    Location:507768
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:573601
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:641673
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:463534
    TPR_12; Tetratricopeptide repeat
  2. NM_001256.6NP_001247.3  cell division cycle protein 27 homolog isoform 2

    See identical proteins and their annotated locations for NP_001247.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AA927469, AC002558, HY023336, S78234
    Consensus CDS
    CCDS11509.1
    UniProtKB/Swiss-Prot
    P30260
    Related
    ENSP00000066544.3, ENST00000066544.8
    Conserved Domains (5) summary
    COG0457
    Location:501762
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:567595
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:635667
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:457528
    TPR_12; Tetratricopeptide repeat
  3. NM_001293089.3NP_001280018.1  cell division cycle protein 27 homolog isoform 3

    See identical proteins and their annotated locations for NP_001280018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AA927469, AC002558, HY023336, U00001
    Consensus CDS
    CCDS74090.1
    UniProtKB/TrEMBL
    G5EA36
    Related
    ENSP00000437339.1, ENST00000527547.5
    Conserved Domains (5) summary
    COG0457
    Location:500761
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:566594
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:634666
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:457527
    TPR_12; Tetratricopeptide repeat
  4. NM_001293091.3NP_001280020.1  cell division cycle protein 27 homolog isoform 4

    See identical proteins and their annotated locations for NP_001280020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region and it thus differs in its 5' UTR and initiates translation at an alternate start codon, and it also uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA927469, AC002558, AK296881, HY023336
    UniProtKB/TrEMBL
    B4DL80
    Conserved Domains (2) summary
    COG0457
    Location:440701
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:506534
    TPR; TPR repeat [structural motif]
  5. NM_001353035.2NP_001339964.1  cell division cycle protein 27 homolog isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (3) summary
    COG0457
    Location:501759
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:567595
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
  6. NM_001353047.2NP_001339976.1  cell division cycle protein 27 homolog isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (3) summary
    COG0457
    Location:500758
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:566594
    TPR; TPR repeat [structural motif]
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
  7. NM_001353049.2NP_001339978.1  cell division cycle protein 27 homolog isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (2) summary
    COG0457
    Location:440698
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:506534
    TPR; TPR repeat [structural motif]
  8. NM_001353050.2NP_001339979.1  cell division cycle protein 27 homolog isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (2) summary
    COG0457
    Location:404665
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:470498
    TPR; TPR repeat [structural motif]
  9. NM_001353051.2NP_001339980.1  cell division cycle protein 27 homolog isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC002558
    Conserved Domains (3) summary
    COG0457
    Location:55238
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:169197
    TPR; TPR repeat [structural motif]
    cl26002
    Location:182414
    TPR_11; TPR repeat

RNA

  1. NR_148340.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC002558

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    47117703..47189295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525548.3XP_011523850.1  cell division cycle protein 27 homolog isoform X4

    See identical proteins and their annotated locations for XP_011523850.1

    Conserved Domains (5) summary
    COG0457
    Location:446707
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:512540
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:580612
    TPR_1; Tetratricopeptide repeat
    pfam13181
    Location:684714
    TPR_8; Tetratricopeptide repeat
    pfam13424
    Location:402473
    TPR_12; Tetratricopeptide repeat
  2. XM_011525549.2XP_011523851.1  cell division cycle protein 27 homolog isoform X4

    See identical proteins and their annotated locations for XP_011523851.1

    Conserved Domains (5) summary
    COG0457
    Location:446707
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:512540
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:580612
    TPR_1; Tetratricopeptide repeat
    pfam13181
    Location:684714
    TPR_8; Tetratricopeptide repeat
    pfam13424
    Location:402473
    TPR_12; Tetratricopeptide repeat
  3. XM_011525546.3XP_011523848.1  cell division cycle protein 27 homolog isoform X1

    Conserved Domains (5) summary
    COG0457
    Location:506767
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:572600
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:640672
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:463533
    TPR_12; Tetratricopeptide repeat
  4. XM_017025485.2XP_016880974.1  cell division cycle protein 27 homolog isoform X7

  5. XM_017025484.2XP_016880973.1  cell division cycle protein 27 homolog isoform X6

  6. XM_017025486.1XP_016880975.1  cell division cycle protein 27 homolog isoform X8

  7. XM_024451052.1XP_024306820.1  cell division cycle protein 27 homolog isoform X5

    Conserved Domains (2) summary
    COG0457
    Location:440701
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:506534
    TPR; TPR repeat [structural motif]
  8. XM_017025488.1XP_016880977.1  cell division cycle protein 27 homolog isoform X9

  9. XM_011525547.3XP_011523849.1  cell division cycle protein 27 homolog isoform X2

    Conserved Domains (5) summary
    COG0457
    Location:507765
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:573601
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:641673
    TPR_1; Tetratricopeptide repeat
    pfam12895
    Location:1792
    ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:463534
    TPR_12; Tetratricopeptide repeat
  10. XM_017025481.2XP_016880970.1  cell division cycle protein 27 homolog isoform X3

RNA

  1. XR_934630.2 RNA Sequence

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