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Dhx33 DEAH-box helicase 33 [ Mus musculus (house mouse) ]

Gene ID: 216877, updated on 18-Apr-2024

Summary

Official Symbol
Dhx33provided by MGI
Official Full Name
DEAH-box helicase 33provided by MGI
Primary source
MGI:MGI:2445102
See related
Ensembl:ENSMUSG00000040620 AllianceGenome:MGI:2445102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx33; 3110057P17Rik; 9430096J02Rik
Summary
Enables DNA-binding transcription factor binding activity; double-stranded RNA binding activity; and rDNA binding activity. Involved in positive regulation of MAPK cascade; regulation of gene expression; and translational initiation. Located in nucleolus and nucleoplasm. Orthologous to human DHX33 (DEAH-box helicase 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 8.9), ovary adult (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 B4; 11 43.21 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70874917..70895258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70984091..71004533, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene nucleoporin 88 Neighboring gene STARR-seq mESC enhancer starr_29882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70783671-70783780 Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene STARR-positive B cell enhancer ABC_E2359 Neighboring gene predicted gene, 22297 Neighboring gene STARR-positive B cell enhancer ABC_E256 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70833281-70833468 Neighboring gene Der1-like domain family, member 2 Neighboring gene RIKEN cDNA 6330403K07 gene Neighboring gene MIS12 kinetochore complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rDNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables rDNA binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NLRP3 inflammasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of canonical inflammasome complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DHX33
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
DEAH box protein 33
putative ATP-dependent RNA helicase DHX33
NP_848144.3
XP_036012469.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178367.4NP_848144.3  ATP-dependent RNA helicase DHX33

    See identical proteins and their annotated locations for NP_848144.3

    Status: VALIDATED

    Source sequence(s)
    AK087592, AL596136, BC052172
    Consensus CDS
    CCDS24971.1
    UniProtKB/Swiss-Prot
    Q80VY9, Q8BS50
    Related
    ENSMUSP00000104167.2, ENSMUST00000108527.8
    Conserved Domains (6) summary
    smart00487
    Location:49252
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:469554
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:83225
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:282399
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:588688
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    pfam11422
    Location:409500
    IBP39; Initiator binding protein 39 kDa

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70874917..70895258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156576.1XP_036012469.1  ATP-dependent RNA helicase DHX33 isoform X1

    Conserved Domains (1) summary
    COG1643
    Location:1523
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]