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DHX33 DEAH-box helicase 33 [ Homo sapiens (human) ]

Gene ID: 56919, updated on 12-Sep-2021

Summary

Official Symbol
DHX33provided by HGNC
Official Full Name
DEAH-box helicase 33provided by HGNC
Primary source
HGNC:HGNC:16718
See related
Ensembl:ENSG00000005100 MIM:614405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDX33
Summary
This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in brain (RPKM 5.2), appendix (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See DHX33 in Genome Data Viewer
Location:
17p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (5440917..5469055, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (5344237..5372302, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene nucleoporin 88 Neighboring gene RPA interacting protein Neighboring gene complement C1q binding protein Neighboring gene DHX33 divergent transcript Neighboring gene derlin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of DEAH (Asp-Glu-Ala-His) box polypeptide 33 (DHX33) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21972, DKFZp762F2011

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rDNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosomal large subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of NLRP3 inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-dependent RNA helicase DHX33
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
DEAH box protein 33
putative ATP-dependent RNA helicase DHX33
NP_001186628.1
NP_064547.2
XP_016880366.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199699.2NP_001186628.1  ATP-dependent RNA helicase DHX33 isoform 2

    See identical proteins and their annotated locations for NP_001186628.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC004148, AK295760, BC030017, BQ775963
    UniProtKB/Swiss-Prot
    Q9H6R0
    UniProtKB/TrEMBL
    B4DIS6
    Related
    ENSP00000458925.1, ENST00000572490.1
    Conserved Domains (5) summary
    smart00847
    Location:305390
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:1522
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:161
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:118235
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:424524
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  2. NM_020162.4NP_064547.2  ATP-dependent RNA helicase DHX33 isoform 1

    See identical proteins and their annotated locations for NP_064547.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004148, AK295760, BQ775963
    Consensus CDS
    CCDS11072.1
    UniProtKB/Swiss-Prot
    Q9H6R0
    UniProtKB/TrEMBL
    B4DIS6
    Related
    ENSP00000225296.3, ENST00000225296.8
    Conserved Domains (5) summary
    smart00847
    Location:478563
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:67695
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:92234
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:291408
    Helicase_C; Helicase conserved C-terminal domain
    pfam07717
    Location:597697
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    5440917..5469055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024877.1XP_016880366.1  ATP-dependent RNA helicase DHX33 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6R0
    Conserved Domains (1) summary
    COG1643
    Location:1267
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_001752570.2 RNA Sequence

  2. XR_934069.2 RNA Sequence

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