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Tek TEK receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 21687, updated on 12-May-2024

Summary

Official Symbol
Tekprovided by MGI
Official Full Name
TEK receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:98664
See related
Ensembl:ENSMUSG00000006386 AllianceGenome:MGI:98664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hyk; STK1; Tie2; Tie-2; Cd202b
Summary
Enables protein tyrosine kinase activity and signaling receptor activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell apoptotic process; and response to retinoic acid. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein import into nucleus; and regulation of NIK/NF-kappaB signaling. Located in perinuclear region of cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 28.4), subcutaneous fat pad adult (RPKM 7.5) and 18 other tissues See more
Orthologs
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Genomic context

See Tek in Genome Data Viewer
Location:
4 C5; 4 43.34 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94627322..94763213)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94739086..94874976)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 74 Neighboring gene STARR-seq mESC enhancer starr_10791 Neighboring gene microRNA 872 Neighboring gene STARR-seq mESC enhancer starr_10792 Neighboring gene predicted gene, 40205 Neighboring gene STARR-seq mESC enhancer starr_10794 Neighboring gene equatorin, sperm acrosome associated Neighboring gene predicted gene 12693

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
enables signaling receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Tie signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Tie signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glomerulus vasculature development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within_positive_effect positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytokine production involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISM
Inferred from Sequence Model
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
angiopoietin-1 receptor
Names
endothelial tyrosine kinase
endothelial-specific receptor tyrosine kinase
p140 TEK
tunica interna endothelial cell kinase
tyrosine kinase with Ig and EGF homology domains-2
tyrosine-protein kinase receptor TEK
tyrosine-protein kinase receptor TIE-2
NP_001277478.1
NP_001277480.1
NP_038718.2
XP_006502993.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290549.1NP_001277478.1  angiopoietin-1 receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001277478.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AL772277, AL954716
    Consensus CDS
    CCDS71421.1
    UniProtKB/Swiss-Prot
    Q02858
    Related
    ENSMUSP00000071162.6, ENSMUST00000071168.6
    Conserved Domains (7) summary
    cd05088
    Location:8141116
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00221
    Location:8221090
    STYKc; Protein kinase; unclassified specificity
    cd00055
    Location:230275
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:638730
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:542625
    fn3; Fibronectin type III domain
    pfam07974
    Location:311340
    EGF_2; EGF-like domain
    pfam10430
    Location:24118
    Ig_Tie2_1; Tie-2 Ig-like domain 1
  2. NM_001290551.1NP_001277480.1  angiopoietin-1 receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001277480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AL772277, AL954716
    Consensus CDS
    CCDS80122.1
    UniProtKB/TrEMBL
    Q80YS4
    Related
    ENSMUSP00000073595.7, ENSMUST00000073939.13
    Conserved Domains (6) summary
    cd05088
    Location:7641066
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00221
    Location:7721040
    STYKc; Protein kinase; unclassified specificity
    cd00055
    Location:179224
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:587679
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:491574
    fn3; Fibronectin type III domain
    pfam10430
    Location:24118
    Ig_Tie2_1; Tie-2 Ig-like domain 1
  3. NM_013690.3NP_038718.2  angiopoietin-1 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_038718.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL772277, AL954716
    Consensus CDS
    CCDS18361.1
    UniProtKB/TrEMBL
    B1AWS8
    Related
    ENSMUSP00000099862.2, ENSMUST00000102798.8
    Conserved Domains (7) summary
    cd05088
    Location:8151117
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00221
    Location:8231091
    STYKc; Protein kinase; unclassified specificity
    cd00055
    Location:230275
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:638730
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:542625
    fn3; Fibronectin type III domain
    pfam07974
    Location:311340
    EGF_2; EGF-like domain
    pfam10430
    Location:24118
    Ig_Tie2_1; Tie-2 Ig-like domain 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    94627322..94763213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502930.4XP_006502993.1  angiopoietin-1 receptor isoform X1

    Conserved Domains (3) summary
    cd05088
    Location:589891
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    cd00063
    Location:412504
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:316398
    fn3; Fibronectin type III domain