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TEK TEK receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 7010, updated on 22-Mar-2020

Summary

Official Symbol
TEKprovided by HGNC
Official Full Name
TEK receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:11724
See related
Ensembl:ENSG00000120156 MIM:600221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B
Summary
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Expression
Broad expression in lung (RPKM 19.9), placenta (RPKM 18.9) and 21 other tissues See more
Orthologs

Genomic context

See TEK in Genome Data Viewer
Location:
9p21.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (27109141..27230178)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (27109147..27230172)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene IFT74 antisense RNA 1 Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19 Neighboring gene RNA, 5S ribosomal pseudogene 280 Neighboring gene ribosomal protein L36a pseudogene 34 Neighboring gene long intergenic non-protein coding RNA 32 Neighboring gene equatorin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
Tie signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
definitive hemopoiesis TAS
Traceable Author Statement
more info
PubMed 
endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerulus vasculature development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart trabecula formation ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of endothelial cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endothelial cell apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of establishment or maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vascular permeability TAS
Traceable Author Statement
more info
PubMed 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
microvillus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
angiopoietin-1 receptor
Names
TEK tyrosine kinase, endothelial
endothelial tyrosine kinase
tunica interna endothelial cell kinase
tyrosine kinase with Ig and EGF homology domains-2
tyrosine-protein kinase receptor TEK
tyrosine-protein kinase receptor TIE-2
NP_000450.3
NP_001277006.1
NP_001277007.1
NP_001362404.1
NP_001362405.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011828.1 RefSeqGene

    Range
    4993..126030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000459.5NP_000450.3  angiopoietin-1 receptor isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL133411, AL355432, AL355433
    Consensus CDS
    CCDS6519.1
    Related
    ENSP00000369375.4, ENST00000380036.9
  2. NM_001290077.1NP_001277006.1  angiopoietin-1 receptor isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK294887, AK295043, AL133411, AL355432, AL355433, BU753127
    Consensus CDS
    CCDS75825.1
    UniProtKB/Swiss-Prot
    Q02763
    Related
    ENSP00000383977.4, ENST00000406359.8
    Conserved Domains (6) summary
    cd05088
    Location:7731075
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00221
    Location:7811049
    STYKc; Protein kinase; unclassified specificity
    cd00055
    Location:230275
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:596688
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:501583
    fn3; Fibronectin type III domain
    pfam10430
    Location:24118
    Ig_Tie2_1; Tie-2 Ig-like domain 1
  3. NM_001290078.1NP_001277007.1  angiopoietin-1 receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001277007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK294887, AL133411, AL355432, AL355433, BU753127
    Consensus CDS
    CCDS78389.1
    UniProtKB/Swiss-Prot
    Q02763
    Related
    ENSP00000430686.1, ENST00000519097.5
    Conserved Domains (5) summary
    cd05088
    Location:668970
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00221
    Location:676944
    STYKc; Protein kinase; unclassified specificity
    cd00055
    Location:126171
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00063
    Location:492584
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:397479
    fn3; Fibronectin type III domain
  4. NM_001375475.1NP_001362404.1  angiopoietin-1 receptor isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL133411, AL355432, AL355433
  5. NM_001375476.1NP_001362405.1  angiopoietin-1 receptor isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AL133411, AL355432, AL355433

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    27109141..27230178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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