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FABP1 fatty acid binding protein 1 [ Homo sapiens (human) ]

Gene ID: 2168, updated on 24-Nov-2020

Summary

Official Symbol
FABP1provided by HGNC
Official Full Name
fatty acid binding protein 1provided by HGNC
Primary source
HGNC:HGNC:3555
See related
Ensembl:ENSG00000163586 MIM:134650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FABPL; L-FABP
Summary
This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011]
Expression
Biased expression in liver (RPKM 2613.3), colon (RPKM 1932.3) and 3 other tissues See more
Orthologs

Genomic context

See FABP1 in Genome Data Viewer
Location:
2p11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (88122982..88128062, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (88422501..88427650, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene skeletal muscle cis-regulatory module upstream of SMYD1 Neighboring gene SET and MYND domain containing 1 Neighboring gene microRNA 4780 Neighboring gene uncharacterized LOC101928347 Neighboring gene threonine synthase like 2 Neighboring gene RNY4 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of fatty acid binding protein 1, liver (FABP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity IDA
Inferred from Direct Assay
more info
PubMed 
bile acid binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
fatty acid binding IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transporter activity IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
intestinal absorption IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
triglyceride catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical cortex IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
peroxisomal matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fatty acid-binding protein, liver
Names
fatty acid binding protein 1, liver
liver-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001443.3NP_001434.1  fatty acid-binding protein, liver

    See identical proteins and their annotated locations for NP_001434.1

    Status: REVIEWED

    Source sequence(s)
    BC022287, BP263155, M10617
    Consensus CDS
    CCDS2001.1
    UniProtKB/Swiss-Prot
    P07148
    UniProtKB/TrEMBL
    Q05CP7, Q6FGL7
    Related
    ENSP00000295834.3, ENST00000295834.8
    Conserved Domains (1) summary
    cl21528
    Location:3127
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    88122982..88128062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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