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Fabp1 fatty acid binding protein 1, liver [ Mus musculus (house mouse) ]

Gene ID: 14080, updated on 1-Mar-2024

Summary

Official Symbol
Fabp1provided by MGI
Official Full Name
fatty acid binding protein 1, liverprovided by MGI
Primary source
MGI:MGI:95479
See related
Ensembl:ENSMUSG00000054422 AllianceGenome:MGI:95479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fabpl; L-FABP
Summary
Enables chromatin binding activity. Predicted to be involved in several processes, including cellular response to hydrogen peroxide; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and positive regulation of fatty acid beta-oxidation. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; liver; and testis. Orthologous to human FABP1 (fatty acid binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 1800.2), liver adult (RPKM 642.4) and 1 other tissue See more
Orthologs
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Genomic context

See Fabp1 in Genome Data Viewer
Location:
6 C1; 6 32.14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71176863..71182018)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71199879..71205034)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16253 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71104939-71105048 Neighboring gene predicted gene, 30391 Neighboring gene predicted gene, 38827 Neighboring gene SET and MYND domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_16258 Neighboring gene STARR-seq mESC enhancer starr_16259 Neighboring gene microRNA 8112 Neighboring gene lysine-rich coiled-coil 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC13855

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
enables bile acid binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables oleic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fatty acid-binding protein, liver
Names
14 kDa selenium-binding protein
fatty acid-binding protein 1
liver-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017399.5NP_059095.1  fatty acid-binding protein, liver

    See identical proteins and their annotated locations for NP_059095.1

    Status: VALIDATED

    Source sequence(s)
    AK131868, AW113370
    Consensus CDS
    CCDS20226.1
    UniProtKB/Swiss-Prot
    P12710
    UniProtKB/TrEMBL
    Q3V2F7
    Related
    ENSMUSP00000064655.8, ENSMUST00000067492.8
    Conserved Domains (1) summary
    cl21528
    Location:3127
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    71176863..71182018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)