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FABP4 fatty acid binding protein 4 [ Homo sapiens (human) ]

Gene ID: 2167, updated on 6-May-2021

Summary

Official Symbol
FABP4provided by HGNC
Official Full Name
fatty acid binding protein 4provided by HGNC
Primary source
HGNC:HGNC:3559
See related
Ensembl:ENSG00000170323 MIM:600434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
aP2; ALBP; AFABP; A-FABP; HEL-S-104
Summary
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 3748.8) and placenta (RPKM 92.5) See more
Orthologs
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Genomic context

See FABP4 in Genome Data Viewer
Location:
8q21.13
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (81478419..81483233, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (82390654..82395468, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene peripheral myelin protein 2 Neighboring gene uncharacterized LOC101927118 Neighboring gene fatty acid binding protein 9 Neighboring gene ferritin heavy chain 1 pseudogene 11 Neighboring gene fatty acid binding protein 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
GeneReviews: Not available
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of fatty acid binding protein 4, adipocyte (FABP4) in primary human brain microvascular endothelial cells PubMed
nucleocapsid gag HIV-1 NC upregulates FABP4 fatty acid binding protein 4, adipocyte in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid binding TAS
Traceable Author Statement
more info
PubMed 
enables hormone receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables long-chain fatty acid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride catabolic process TAS
Traceable Author Statement
more info
 
involved_in white fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in lipid droplet TAS
Traceable Author Statement
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
fatty acid-binding protein, adipocyte
Names
adipocyte fatty acid binding protein
adipocyte lipid-binding protein
adipocyte-type fatty acid-binding protein
epididymis secretory protein Li 104
fatty acid binding protein 4, adipocyte

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001442.3NP_001433.1  fatty acid-binding protein, adipocyte

    See identical proteins and their annotated locations for NP_001433.1

    Status: REVIEWED

    Source sequence(s)
    AC018616, BC003672, BQ880795
    Consensus CDS
    CCDS6230.1
    UniProtKB/Swiss-Prot
    P15090
    UniProtKB/TrEMBL
    E7DVW4
    Related
    ENSP00000256104.4, ENST00000256104.5
    Conserved Domains (1) summary
    cd19467
    Location:2131
    FABP4; fatty acid binding protein 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    81478419..81483233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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