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Fabp4 fatty acid binding protein 4, adipocyte [ Mus musculus (house mouse) ]

Gene ID: 11770, updated on 1-Mar-2024

Summary

Official Symbol
Fabp4provided by MGI
Official Full Name
fatty acid binding protein 4, adipocyteprovided by MGI
Primary source
MGI:MGI:88038
See related
Ensembl:ENSMUSG00000062515 AllianceGenome:MGI:88038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ap2; P15; ALBP; Lbpl; AFABP; 422/aP2; ALBP/Ap2
Summary
Enables hormone receptor binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transporter activity. Involved in long-chain fatty acid transport and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; cellular response to lithium ion; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and heart. Orthologous to human FABP4 (fatty acid binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 1709.3), genital fat pad adult (RPKM 1107.4) and 4 other tissues See more
Orthologs
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Genomic context

See Fabp4 in Genome Data Viewer
Location:
3 A1; 3 2.56 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (10269406..10273653, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (10204342..10208616, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene peripheral myelin protein 2 Neighboring gene fatty acid binding protein 9, testis Neighboring gene STARR-seq mESC enhancer starr_06936 Neighboring gene STARR-positive B cell enhancer ABC_E10175 Neighboring gene fatty acid binding protein 12 Neighboring gene STARR-seq mESC enhancer starr_06939 Neighboring gene predicted gene, 37316 Neighboring gene inositol (myo)-1(or 4)-monophosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables long-chain fatty acid transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to lithium ion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in long-chain fatty acid transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within white fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fatty acid-binding protein, adipocyte
Names
3T3-L1 lipid-binding protein
P2 adipocyte protein
adipocyte lipid-binding protein
adipocyte protein aP2
adipocyte-type fatty acid-binding protein
fatty acid-binding protein 4
myelin P2 protein homolog
protein 422

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409513.1NP_001396442.1  fatty acid-binding protein, adipocyte isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113990
  2. NM_001409514.1NP_001396443.1  fatty acid-binding protein, adipocyte isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113990
  3. NM_024406.4NP_077717.1  fatty acid-binding protein, adipocyte isoform 1

    See identical proteins and their annotated locations for NP_077717.1

    Status: VALIDATED

    Source sequence(s)
    AC113990
    Consensus CDS
    CCDS17238.1
    UniProtKB/Swiss-Prot
    P04117
    UniProtKB/TrEMBL
    Q542H7
    Related
    ENSMUSP00000029041.5, ENSMUST00000029041.6
    Conserved Domains (1) summary
    cd19467
    Location:2131
    FABP4; fatty acid binding protein 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    10269406..10273653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530048.4XP_006530111.1  fatty acid-binding protein, adipocyte isoform X1

    Conserved Domains (1) summary
    cl10502
    Location:282
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family