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F2RL1 F2R like trypsin receptor 1 [ Homo sapiens (human) ]

Gene ID: 2150, updated on 17-Oct-2021

Summary

Official Symbol
F2RL1provided by HGNC
Official Full Name
F2R like trypsin receptor 1provided by HGNC
Primary source
HGNC:HGNC:3538
See related
Ensembl:ENSG00000164251 MIM:600933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR2; GPR11
Summary
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]
Expression
Broad expression in colon (RPKM 30.3), duodenum (RPKM 21.7) and 16 other tissues See more
Orthologs
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Genomic context

See F2RL1 in Genome Data Viewer
Location:
5q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (76819030..76835315)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76114855..76131140)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene non-protein coding RNA, upstream of F2R/PAR1 Neighboring gene coagulation factor II thrombin receptor Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene S100 calcium binding protein Z Neighboring gene RNA, U6atac small nuclear 36, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G-protein alpha-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G-protein beta-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables thrombin-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in establishment of endothelial barrier IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mature conventional dendritic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mature conventional dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytokine production involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of eosinophil degranulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interferon-gamma production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neutrophil mediated killing of gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pseudopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of renin secretion into blood stream ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of chemokine (C-X-C motif) ligand 2 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in thrombin-activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within_positive_effect vasodilation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in pseudopodium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteinase-activated receptor 2
Names
G-protein coupled receptor 11
coagulation factor II (thrombin) receptor-like 1
protease-activated receptor 2
thrombin receptor-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005242.6NP_005233.4  proteinase-activated receptor 2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC010621
    Consensus CDS
    CCDS4033.1
    Related
    ENSP00000296677.4, ENST00000296677.5
    Conserved Domains (1) summary
    cd15370
    Location:76355
    7tmA_PAR2; protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    76819030..76835315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009223.1XP_016864712.1  proteinase-activated receptor 2 isoform X1

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