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F2RL1 F2R like trypsin receptor 1 [ Homo sapiens (human) ]

Gene ID: 2150, updated on 14-Oct-2018

Summary

Official Symbol
F2RL1provided by HGNC
Official Full Name
F2R like trypsin receptor 1provided by HGNC
Primary source
HGNC:HGNC:3538
See related
Ensembl:ENSG00000164251 MIM:600933; Vega:OTTHUMG00000102118
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR2; GPR11
Summary
This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016]
Expression
Broad expression in colon (RPKM 30.3), duodenum (RPKM 21.7) and 16 other tissues See more
Orthologs

Genomic context

See F2RL1 in Genome Data Viewer
Location:
5q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (76818977..76835315)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76114833..76131140)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene non-protein coding RNA, upstream of F2R/PAR1 Neighboring gene coagulation factor II thrombin receptor Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene S100 calcium binding protein Z Neighboring gene RNA, U6atac small nuclear 36, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • African trypanosomiasis, organism-specific biosystem (from KEGG)
    African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
  • African trypanosomiasis, conserved biosystem (from KEGG)
    African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
G-protein alpha-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
G-protein beta-subunit binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
thrombin-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemokine (C-C motif) ligand 2 secretion IDA
Inferred from Direct Assay
more info
PubMed 
chemokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
establishment of endothelial barrier IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-10 secretion IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
mature conventional dendritic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
mature conventional dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chemokine secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel diameter ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine secretion involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of eosinophil degranulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil mediated killing of gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pseudopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of renin secretion into blood stream ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
thrombin-activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
pseudopodium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
proteinase-activated receptor 2
Names
G-protein coupled receptor 11
coagulation factor II (thrombin) receptor-like 1
protease-activated receptor 2
thrombin receptor-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005242.5NP_005233.3  proteinase-activated receptor 2 preproprotein

    See identical proteins and their annotated locations for NP_005233.3

    Status: REVIEWED

    Source sequence(s)
    BC012453, BC018130, DB463838
    Consensus CDS
    CCDS4033.1
    UniProtKB/Swiss-Prot
    P55085
    Related
    ENSP00000296677.4, OTTHUMP00000128315, ENST00000296677.4, OTTHUMT00000219957
    Conserved Domains (1) summary
    cd15370
    Location:76355
    7tmA_PAR2; protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    76818977..76835315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009223.1XP_016864712.1  proteinase-activated receptor 2 isoform X1

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