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F2rl1 coagulation factor II (thrombin) receptor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 14063, updated on 21-May-2023

Summary

Official Symbol
F2rl1provided by MGI
Official Full Name
coagulation factor II (thrombin) receptor-like 1provided by MGI
Primary source
MGI:MGI:101910
See related
Ensembl:ENSMUSG00000021678 AllianceGenome:MGI:101910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Par2; PAR-2; Gpcr11
Summary
Enables G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including mature conventional dendritic cell differentiation; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Located in pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Par2 (Gene ID: 109447) and F2rl1 (Gene ID: 14063) share the Par2 symbol/alias in common. Par2 is a widely used alternative name for coagulation factor II (thrombin) receptor-like 1 (F2rl1), which can be confused with the official symbol for Par2, pulmonary adenoma resistance 2 (Par2). [14 Aug 2020]
Expression
Broad expression in colon adult (RPKM 22.6), large intestine adult (RPKM 21.9) and 15 other tissues See more
Orthologs
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Genomic context

See F2rl1 in Genome Data Viewer
Location:
13 D1; 13 49.53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95648226..95661748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95511718..95525240, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene corticotropin releasing hormone binding protein Neighboring gene predicted gene, 52025 Neighboring gene S100 calcium binding protein, zeta Neighboring gene predicted gene, 53807 Neighboring gene predicted gene, 32640 Neighboring gene coagulation factor II (thrombin) receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G-protein alpha-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables G-protein beta-subunit binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heterotrimeric G-protein binding TAS
Traceable Author Statement
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables proteinase-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables thrombin-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell junction maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mature conventional dendritic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mature conventional dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of eosinophil degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil mediated killing of gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pseudopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of renin secretion into blood stream IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium channel activating, G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in thrombin-activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within_positive_effect vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_positive_effect vasodilation ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proteinase-activated receptor 2
Names
G-protein coupled receptor 11
Protease-activated receptor-2
coagulation factor II receptor-like 1
thrombin receptor-like 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007974.4NP_032000.3  proteinase-activated receptor 2 precursor

    See identical proteins and their annotated locations for NP_032000.3

    Status: VALIDATED

    Source sequence(s)
    AK160916, BY029876, DV551864
    Consensus CDS
    CCDS26700.1
    UniProtKB/Swiss-Prot
    P55086
    UniProtKB/TrEMBL
    Q3TU81
    Related
    ENSMUSP00000022185.9, ENSMUST00000022185.10
    Conserved Domains (2) summary
    pfam00001
    Location:95346
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:156363
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95648226..95661748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)