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Duox2 dual oxidase 2 [ Mus musculus (house mouse) ]

Gene ID: 214593, updated on 15-Apr-2019

Summary

Official Symbol
Duox2provided by MGI
Official Full Name
dual oxidase 2provided by MGI
Primary source
MGI:MGI:3036280
See related
Ensembl:ENSMUSG00000068452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LNOX2; THOX2; NOXEF2; P138-TOX; A430065P05Rik
Expression
Biased expression in large intestine adult (RPKM 68.1), small intestine adult (RPKM 25.6) and 2 other tissues See more
Orthologs

Genomic context

See Duox2 in Genome Data Viewer
Location:
2; 2 E5
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (122279246..122298742, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (122106173..122123901, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S12, pseudogene 10 Neighboring gene sorbitol dehydrogenase Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
superoxide-generating NADPH oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adenohypophysis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
inner ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
response to cAMP ISO
Inferred from Sequence Orthology
more info
 
response to virus ISO
Inferred from Sequence Orthology
more info
 
superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual oxidase 2
XP_006499173.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362755.1NP_001349684.1  dual oxidase 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL844566
    Conserved Domains (5) summary
    cd06186
    Location:12711545
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:10851229
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam13499
    Location:857929
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    122279246..122298742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499110.2XP_006499173.1  dual oxidase 2 isoform X1

    Related
    ENSMUSP00000158204.1, ENSMUST00000237546.1
    Conserved Domains (5) summary
    cd06186
    Location:12711545
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:10851229
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam13499
    Location:857929
    EF-hand_7; EF-hand domain pair

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177610.2: Suppressed sequence

    Description
    NM_177610.2: This RefSeq was removed because currently there is insufficient support for the transcript.
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