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DUOX2 dual oxidase 2 [ Homo sapiens (human) ]

Gene ID: 50506, updated on 13-Feb-2019

Summary

Official Symbol
DUOX2provided by HGNC
Official Full Name
dual oxidase 2provided by HGNC
Primary source
HGNC:HGNC:13273
See related
Ensembl:ENSG00000140279 MIM:606759
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDH6; LNOX2; THOX2; NOXEF2; P138-TOX
Summary
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
Expression
Biased expression in gall bladder (RPKM 216.4), thyroid (RPKM 55.7) and 3 other tissues See more
Orthologs

Genomic context

See DUOX2 in Genome Data Viewer
Location:
15q21.1
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (45092648..45114161, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45384851..45406537, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 78, pseudogene Neighboring gene sorbitol dehydrogenase Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Amine-derived hormones, organism-specific biosystem (from REACTOME)
    Amine-derived hormones, organism-specific biosystemCatecholamines and thyroxine are synthesized from tyrosine, and serotonin and melatonin from tryptophan.
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
    Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...
  • Thyroid hormone synthesis, organism-specific biosystem (from KEGG)
    Thyroid hormone synthesis, organism-specific biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
  • Thyroid hormone synthesis, conserved biosystem (from KEGG)
    Thyroid hormone synthesis, conserved biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
  • Thyroxine biosynthesis, organism-specific biosystem (from REACTOME)
    Thyroxine biosynthesis, organism-specific biosystemThyroxine (3,5,3',5'-tetraiodothyronine, T4) promotes normal growth and development. It also regulates heat and energy production. T4 is released from the thyroid gland, the largest endocrine organ i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)H oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD(P)H oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
superoxide-generating NADPH oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
adenohypophysis morphogenesis IEA
Inferred from Electronic Annotation
more info
 
bone mineralization IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cuticle development ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fertilization IEA
Inferred from Electronic Annotation
more info
 
hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell motility IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of wound healing IGI
Inferred from Genetic Interaction
more info
PubMed 
response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide anion generation IGI
Inferred from Genetic Interaction
more info
PubMed 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone generation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell leading edge IGI
Inferred from Genetic Interaction
more info
PubMed 
cell surface IGI
Inferred from Genetic Interaction
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dual oxidase 2
Names
NADH/NADPH thyroid oxidase p138-tox
NADPH oxidase/peroxidase DUOX2
NADPH thyroid oxidase 2
dual oxidase-like domains 2
flavoprotein NADPH oxidase
large NOX 2
long NOX 2
nicotinamide adenine dinucleotide phosphate oxidase
p138 thyroid oxidase
thyroid oxidase 2
NP_054799.4
XP_005254478.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009447.1 RefSeqGene

    Range
    5001..26508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363711.1NP_001350640.1  dual oxidase 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC091117
    Consensus CDS
    CCDS86454.1
    Conserved Domains (6) summary
    cd06186
    Location:12741548
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:10881223
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam13499
    Location:857929
    EF-hand_7; EF-hand domain pair
    cl25352
    Location:764858
    EFh_PEF; The penta-EF hand (PEF) family
  2. NM_014080.4NP_054799.4  dual oxidase 2 precursor

    See identical proteins and their annotated locations for NP_054799.4

    Status: REVIEWED

    Source sequence(s)
    AC091117, AF230496, BI045475
    Consensus CDS
    CCDS10117.1
    UniProtKB/Swiss-Prot
    Q9NRD8
    Related
    ENSP00000475084.1, ENST00000603300.1
    Conserved Domains (6) summary
    cd06186
    Location:12741548
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:10881223
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:36547
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:824884
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    45092648..45114161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254421.3XP_005254478.1  dual oxidase 2 isoform X1

    UniProtKB/TrEMBL
    X6RAN8
    Related
    ENSP00000373691.6, ENST00000389039.10
    Conserved Domains (6) summary
    cd06186
    Location:12741548
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38594
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:824885
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:10881223
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam13499
    Location:857929
    EF-hand_7; EF-hand domain pair
    cl25352
    Location:764858
    EFh_PEF; The penta-EF hand (PEF) family
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