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Tagln2 transgelin 2 [ Mus musculus (house mouse) ]

Gene ID: 21346, updated on 5-Mar-2024

Summary

Official Symbol
Tagln2provided by MGI
Official Full Name
transgelin 2provided by MGI
Primary source
MGI:MGI:1312985
See related
Ensembl:ENSMUSG00000026547 AllianceGenome:MGI:1312985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sm22B; Sm22a; SM22beta; 2700094C18Rik
Summary
Predicted to be involved in epithelial cell differentiation. Predicted to be active in cytoskeleton. Is expressed in several structures, including autopod; cardiovascular system; gut; hemolymphoid system gland; and telencephalon ventricular layer. Orthologous to human TAGLN2 (transgelin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 455.3), lung adult (RPKM 276.3) and 19 other tissues See more
Orthologs
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Genomic context

Location:
1 H3; 1 79.89 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172327813..172334942)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172500246..172507375)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4391 Neighboring gene SLAM family member 9 Neighboring gene immunoglobulin superfamily, member 9 Neighboring gene STARR-positive B cell enhancer ABC_E2587 Neighboring gene STARR-positive B cell enhancer ABC_E9066 Neighboring gene STARR-seq mESC enhancer starr_03067 Neighboring gene STARR-positive B cell enhancer ABC_E7779 Neighboring gene cilia and flagella associated protein 45 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174458799-174459099 Neighboring gene RIKEN cDNA 4933439K11 gene Neighboring gene STARR-seq mESC enhancer starr_03068 Neighboring gene V-set and immunoglobulin domain containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0120

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
transgelin-2
Names
SM22-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178598.2NP_848713.1  transgelin-2

    See identical proteins and their annotated locations for NP_848713.1

    Status: VALIDATED

    Source sequence(s)
    AK151576
    Consensus CDS
    CCDS35784.1
    UniProtKB/Swiss-Prot
    Q3TIB8, Q6A0C6, Q78ZX2, Q91VU2, Q9WVA4
    Related
    ENSMUSP00000106861.2, ENSMUST00000111230.8
    Conserved Domains (3) summary
    COG5199
    Location:14188
    SCP1; Calponin [Cytoskeleton]
    cd00014
    Location:25136
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam00402
    Location:174197
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    172327813..172334942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)