Format

Send to:

Choose Destination

TAGLN2 transgelin 2 [ Homo sapiens (human) ]

Gene ID: 8407, updated on 4-Oct-2020

Summary

Official Symbol
TAGLN2provided by HGNC
Official Full Name
transgelin 2provided by HGNC
Primary source
HGNC:HGNC:11554
See related
Ensembl:ENSG00000158710 MIM:604634
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA1756
Summary
The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in lung (RPKM 268.8), stomach (RPKM 231.0) and 25 other tissues See more
Orthologs

Genomic context

See TAGLN2 in Genome Data Viewer
Location:
1q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (159918111..159925507, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159887897..159895332, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 28 Neighboring gene uncharacterized LOC107985216 Neighboring gene V-set and immunoglobulin domain containing 8 Neighboring gene cilia and flagella associated protein 45 Neighboring gene microRNA 4259 Neighboring gene immunoglobulin superfamily member 9 Neighboring gene SLAM family member 9 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transgelin 2 (TAGLN2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of transgelin-2 in umbilical cord blood mononuclear cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transgelin 2 (TAGLN2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
transgelin-2
Names
SM22-alpha homolog
epididymis secretory sperm binding protein
epididymis tissue protein Li 7e

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277223.2NP_001264152.1  transgelin-2 isoform b

    See identical proteins and their annotated locations for NP_001264152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon and begins translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AI270594, AK291562, AL513485, CF128621
    Consensus CDS
    CCDS1189.1
    UniProtKB/Swiss-Prot
    P37802
    Related
    ENSP00000357075.1, ENST00000320307.8
    Conserved Domains (2) summary
    pfam00307
    Location:26133
    CH; Calponin homology (CH) domain
    pfam00402
    Location:174197
    Calponin; Calponin family repeat
  2. NM_001277224.2NP_001264153.1  transgelin-2 isoform a

    See identical proteins and their annotated locations for NP_001264153.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL513485, AY007127
    Consensus CDS
    CCDS60314.1
    UniProtKB/Swiss-Prot
    P37802
    Related
    ENSP00000357076.1, ENST00000368096.5
    Conserved Domains (2) summary
    pfam00307
    Location:47154
    CH; Calponin homology (CH) domain
    pfam00402
    Location:195218
    Calponin; Calponin family repeat
  3. NM_003564.3NP_003555.1  transgelin-2 isoform b

    See identical proteins and their annotated locations for NP_003555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon and begins translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AI270594, AK291562
    Consensus CDS
    CCDS1189.1
    UniProtKB/Swiss-Prot
    P37802
    Related
    ENSP00000357077.4, ENST00000368097.8
    Conserved Domains (2) summary
    pfam00307
    Location:26133
    CH; Calponin homology (CH) domain
    pfam00402
    Location:174197
    Calponin; Calponin family repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    159918111..159925507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center